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          Abstract

          Over the past years, the Netherlands Heart Journal (NHJ) has seen a considerable increase in the total number of submissions. Since NHJ was accepted by PubMed in 2007, the total number of submissions has more than doubled (Table 1). In each major article category (case report, original article, review article, imaging in cardiology) an increase could be observed. However, the increasing number of submissions together with a fixed space for publication has resulted in higher rejection rates. On one hand, this allows a more critical attitude towards the scientific level of a certain article, on the other hand we have to disappoint more authors. This holds in particular for case reports, which can only be accepted if they provide truly novel information. The only other way out for a case report is the transfer to the imaging article category, if the enclosed image is of indisputable value. In general, we discourage our readers from submitting case reports unless the case histories contain ‘prime time news’. We are delighted to see a considerable rise in both original and review articles. These categories of articles reflect the scientific quality of a journal. Apart from their inherent scientific value, journal editors highly welcome such articles because of their citation value. Usually, both original and review articles are highly cited which may directly lead to an improved impact factor. Table 1 Submissions to NHJ by year and article type 2008 2009 2010 Submissions 79 172 231 Overall rejection rate 21% 31% 41% Case reports 33 46 68 Original articles 31 61 72 Review articles 14 15 18 Imaging in cardiology 10 26 47 Other 16 24 26 Figure 1 shows the number of published items over a period of 4 years (2007–2010). The number of publications is fairly constant over the years with a mean of 120 publications per year. However, when looking at the number of citations, there has been a steep rise over the past 3 years (52 citations in 2008, 200 in 2009, and 288 citations in 2010). Since the calculation of an impact factor relies on the number of citations divided by the number of published items, it may be presaged that the NHJ impact factor will improve over time (Fig. 2). Fig. 1 Number of NHJ articles 2007–2010 (n = 477) (data derived from ISI Web of Knowledge-Web of Science) Fig. 2 Number of NHJ citations 2007–2010 (n = 547) (data derived from ISI Web of Knowledge-Web of Science) When looking at the top-10 journals that cite NHJ articles (Table 2), it is rewarding to see that the most important cardiovascular journals are involved, i.e. Circulation, Journal of the American College of Cardiology (JACC), and the European Heart Journal; Circulation and JACC even take place 2 and place 3, respectively. Table 2 Top-10 journals citing NHJ 1 International Journal of Cardiovascular Imaging 2 Circulation 3 Journal of the American College of Cardiology 4 International Journal of Cardiology 5 Europace 6 Cardiovascular Research 7 Heart 8 Journal of Nuclear Cardiology 9 European Heart Journal 10 Catheterization and Cardiovascular Interventions In Table 3 we show the top-10 cited NHJ articles from 2007 to 2010. It is noteworthy (and somewhat surprising) to observe that not only original or review articles are being cited but also case reports and articles from the imaging category. This indicates that each article category may provide citable items. Table 3 Top-10 cited NHJ articles from 2007 to 2010 1 van Vliet P, Roccio M, Smits AM, et al. Progenitor cells isolated from the human heart: a potential cell source for regenerative therapy (Original article)[1] 2 Schuijf JD, Bax JJ, van der Wall EE. Anatomical and functional imaging techniques: basically similar or fundamentally different? (Review article)[2] 3 Rensen SSM, Doevendans PAFM, van Eys GJJM. Regulation and characteristics of vascular smooth muscle cell phenotypic diversity (Review article)[3] 4 Nijveldt R, Beek AM, Hirsch A, et al. ‘No-reflow’ after acute myocardial infarction: direct visualisation of microvascular obstruction by gadolinium-enhanced CMR (Review article)[4] 5 Wijpkema JS, Dorgelo J, Willems TP, et al. Discordance between anatomical and functional coronary stenosis severity (Original article)[5] 6 De Leeuw JG, Wardeh A, Sramek A, et al. Pseudo-aortic dissection after primary PCI (Imaging)[6] 7 ten Kate GJR, Weustink AC, de Feyter PJ. Coronary artery anomalies detected by MSCT-coronary angiography in the adult (Original article)[7] 8 Chamuleau SAJ, van Eck-Smit BLF, Meuwissen M, et al. Long-term prognostic value of CFVR and FFR versus perfusion scintigraphy in patients with multivessel disease (Original article)[8] 9 van de Wal RMA, van Werkum JW, d’Armandville MCL, et al. Giant aneurysm of an aortocoronary venous bypass graft compressing the right ventricle (Case report)[9] 10 Juwana YB, Wirianta J, Suryapranata H, et al. Left main coronary artery stenosis undetected by 64-slice computed tomography: a word of caution (Case report)[10] As the acceptance of articles is dependent on intensive peer review, we express our gratitude to the reviewers of the Netherlands Heart Journal. Lastly, we thank all authors for sending us their fine research and we hope that they will continue to do so in the near future.

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          Regulation and characteristics of vascular smooth muscle cell phenotypic diversity.

          Vascular smooth muscle cells can perform both contractile and synthetic functions, which are associated with and characterised by changes in morphology, proliferation and migration rates, and the expression of different marker proteins. The resulting phenotypic diversity of smooth muscle cells appears to be a function of innate genetic programmes and environmental cues, which include biochemical factors, extracellular matrix components, and physical factors such as stretch and shear stress. Because of the diversity among smooth muscle cells, blood vessels attain the flexibility that is necessary to perform efficiently under different physiological and pathological conditions. In this review, we discuss recent literature demonstrating the extent and nature of smooth muscle cell diversity in the vascular wall and address the factors that affect smooth muscle cell phenotype. (Neth Heart J 2007;15:100-8.).
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            Progenitor cells isolated from the human heart: a potential cell source for regenerative therapy.

            In recent years, resident cardiac progenitor cells have been identified in, and isolated from the rodent heart. These cells show the potential to form cardiomyocytes, smooth muscle cells, and endothelial cells in vitro and in vivo and could potentially be used as a source for cardiac repair. However, previously described cardiac progenitor cell populations show immature development and need co-culture with neonatal rat cardiomyocytes in order to differentiate in vitro. Here we describe the localisation, isolation, characterisation, and differentiation of cardiomyocyte progenitor cells (CMPCs) isolated from the human heart. hCMPCs were identified in human hearts based on Sca-1 expression. These cells were isolated, and FACS, RT-PCR and immunocytochemistry were used to determine their baseline characteristics. Cardiomyogenic differentiation was induced by stimulation with 5-azacytidine. hCMPCs were localised within the atria, atrioventricular region, and epicardial layer of the foetal and adult human heart. In vitro, hCMPCs could be induced to differentiate into cardiomyocytes and formed spontaneously beating aggregates, without the need for co-culture with neonatal cardiomyocytes. The human heart harbours a pool of resident cardiomyocyte progenitor cells, which can be expanded and differentiated in vitro. These cells may provide a suitable source for cardiac regeneration cell therapy. (Neth Heart J 2008;16:163-9.).
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              Anatomical and functional imaging techniques: basically similar or fundamentally different?

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                Author and article information

                Contributors
                e.e.van_der_wall@lumc.nl
                Journal
                Neth Heart J
                Netherlands Heart Journal
                Bohn Stafleu van Loghum (Heidelberg )
                1568-5888
                1876-6250
                3 March 2011
                3 March 2011
                April 2011
                : 19
                : 4
                : 159-161
                Affiliations
                [1 ]Department of Cardiology, Leiden University Medical Center, P.O. Box 9600, Leiden, the Netherlands
                [2 ]Department of Cardiology, University Medical Center Nijmegen, Nijmegen, the Netherlands
                [3 ]Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands
                [4 ]Department of Cardiology, Academic Medical Center Amsterdam, Amsterdam, the Netherlands
                [5 ]Department of Cardiology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands
                Article
                99
                10.1007/s12471-011-0099-z
                3058508
                21475678
                ca58ebbb-9a28-4e77-8918-38fb50d00e86
                © The Author(s) 2011
                History
                Categories
                Editorial
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                © Springer Media / Bohn Stafleu van Loghum 2011

                Cardiovascular Medicine
                Cardiovascular Medicine

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