ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice.

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Abstract

Pregnancies in women with the antiphospholipid syndrome (APS) are frequently complicated by fetal loss and intrauterine growth restriction (IUGR). How circulating antiphospholipid antibodies (aPL) cause pregnancy complications in APS is poorly understood. We sought to determine whether the low-density lipoprotein receptor family member apolipoprotein E receptor 2 (ApoER2) mediates trophoblast dysfunction and pregnancy complications induced by aPL.

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Journal

Journal ID (iso-abbrev):

Title: Arthritis & rheumatology (Hoboken, N.J.)

Publisher: Wiley-Blackwell

ISSN (Electronic): 2326-5205

ISSN (Print): 2326-5191

Publication date (Electronic): Mar 2016

Volume: 68

Issue: 3

Affiliations

[1 ] University of Texas Southwestern Medical Center, Dallas.

[2 ] Weill Cornell Medical College, New York, New York.

[3 ] Hospital for Special Surgery and Weill Cornell Medical College, New York, New York.

[4 ] University Medical Center Utrecht, Utrecht, The Netherlands.

[5 ] University of California at San Diego, La Jolla.

[6 ] Yale University School of Medicine, New Haven, Connecticut.

Article

Mid ID: NIHMS740160

DOI: 10.1002/art.39453

PMC ID: 4767551

PubMed ID: 26474194

SO-VID: ca5ade89-1628-4c25-9202-7e6abbad5864

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