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      Use of Hirulog in the prevention of venous thrombosis after major hip or knee surgery.

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          Abstract

          The study objective was to determine whether Hirulog, a direct thrombin inhibitor, has potential efficacy and safety in the prevention of deep vein thrombosis (DVT) in orthopedic patients. A phase 2 open-label, dose-escalating design was used to study 222 unselected patients undergoing major hip or knee surgery in tertiary-care, university-affiliated hospitals.

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          Author and article information

          Journal
          Circulation
          Circulation
          Ovid Technologies (Wolters Kluwer Health)
          0009-7322
          0009-7322
          Nov 1994
          : 90
          : 5
          Affiliations
          [1 ] Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
          Article
          10.1161/01.cir.90.5.2385
          7955198
          ca69a20d-2daa-41a4-b4a6-714c6317e0e2
          History

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