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      A novel E2F/sphingosine kinase 1 axis regulates anthracycline response in squamous cell carcinoma.

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          Abstract

          Head and neck squamous cell carcinomas (HNSCC) are frequently drug resistant and have a mortality rate of 45%. We have previously shown that E2F7 may contribute to drug resistance in SCC cells. However, the mechanism and pathways involved remain unknown.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Clin. Cancer Res.
          Title: Clinical cancer research : an official journal of the American Association for Cancer Research
          Publisher: American Association for Cancer Research (AACR)
          ISSN: 1078-0432
          ISSN (Print): 1078-0432
          Publication date (Electronic): Jan 15 2015
          Volume: 21
          Issue: 2
          Affiliations
          [1 ] Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Translational Research Institute, Woolloongabba, Queensland, Australia.
          [2 ] Department of Pathology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
          [3 ] Department of Medical Oncology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
          [4 ] Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Translational Research Institute, Woolloongabba, Queensland, Australia. nsaunders@uq.edu.au.
          Article
          Publisher Item ID: 1078-0432.CCR-14-1962
          DOI: 10.1158/1078-0432.CCR-14-1962
          PubMed ID: 25411162
          SO-VID: ca6ba93b-cb30-4ba7-8183-e5e34defd1eb
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