0
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      The Power to Detect Cultural Transmission in the Nuclear Twin Family Design With and Without Polygenic Risk Scores and in the Transmitted-Nontransmitted (Alleles) Design.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          We compare the power of two different approaches to detect passive genotype-environment (GE) covariance originating from cultural and genetic transmission operating simultaneously. In the traditional nuclear twin family (NTF) design, cultural transmission is estimated from the phenotypic covariance matrices of the mono- and dizygotic twins and their parents. Here, phenotyping is required in all family members. A more recent method is the transmitted-nontransmitted (T-NT) allele design, which exploits measured genetic variants in parents and offspring to test for effects of nontransmitted alleles from parents. This design requires two-generation genome-wide data and a powerful genome-wide association study (GWAS) for the phenotype in addition to phenotyping in offspring. We compared the power of both designs. Using exact data simulation, we demonstrate three points: how the power of the T-NT design depends on the predictive power of polygenic risk scores (PRSs); that when the NTF design can be applied, its power to detect cultural transmission and GE covariance is high relative to T-NT; and that, given effect sizes from contemporary GWAS, adding PRSs to the NTF design does not yield an appreciable increase in the power to detect cultural transmission. However, it may be difficult to collect phenotypes of parents and the possible importance of gene × age interaction, and secular generational effects can cause complications for many important phenotypes. The T-NT design avoids these complications.

          Related collections

          Author and article information

          Journal
          Twin Res Hum Genet
          Twin research and human genetics : the official journal of the International Society for Twin Studies
          Cambridge University Press (CUP)
          1832-4274
          1832-4274
          October 2020
          : 23
          : 5
          Affiliations
          [1 ] Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
          [2 ] Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
          Article
          S1832427420000766
          10.1017/thg.2020.76
          33059787
          ca7ee097-7ce4-418c-b290-7552bb61ea34
          History

          genetic nurture,nuclear twin family design,nontransmitted alleles,cultural transmission,power

          Comments

          Comment on this article