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      Effect of Nonsuckling Period on Pituitary Prolactin Secretory Activity in Rats

      ,

      Hormone Research in Paediatrics

      S. Karger AG

      Prolactin, Lactation, Nonsuckling, Resuckling, Radioimmunoassay, Synthesis, Release

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          Abstract

          To study the effect of nonsuckling period on the response of pituitary prolactin secretion to resuckling, the pituitary and serum prolactin levels and synthesis and release of prolactin of the pituitary in vitro before and/or after resuckling following various lengths of nonsuckling period were measured by radioimmunoassay or by the technique of <sup>14</sup>C-leucine incorporation into prolactin in primiparous Sprague-Dawley rats.The pituitary prolactin content and concentration increased after 8 h of nonsuckling and then gradually decreased. Nevertheless, serum prolactin concentration after 3 and 10 min of resuckling and prolactin released from the pituitary in vitro were higher in the rats with 24 h of the nonsuckling period than in the rats with 8, and 16 h of the nonsuckling period. These results suggest that prolactin secretion, especially its release, was intensively inhibited until about 16 h, but apparently recovered at 24 h of the nonsuckling period. The significance of these findings was discussed.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1973
          1973
          21 November 2008
          : 4
          : 3
          : 169-176
          Affiliations
          Pharmacology Division, National Cancer Center Research Institute, Tokyo
          Article
          178305 Horm Res 1973;4:169–176
          10.1159/000178305
          4748472
          © 1973 S. Karger AG, Basel

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          Pages: 8
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