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      Importing Mitochondrial Proteins: Machineries and Mechanisms

      , , , ,
      Cell
      Elsevier BV

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          Abstract

          Most mitochondrial proteins are synthesized on cytosolic ribosomes and must be imported across one or both mitochondrial membranes. There is an amazingly versatile set of machineries and mechanisms, and at least four different pathways, for the importing and sorting of mitochondrial precursor proteins. The translocases that catalyze these processes are highly dynamic machines driven by the membrane potential, ATP, or redox reactions, and they cooperate with molecular chaperones and assembly complexes to direct mitochondrial proteins to their correct destinations. Here, we discuss recent insights into the importing and sorting of mitochondrial proteins and their contributions to mitochondrial biogenesis.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          00928674
          August 2009
          August 2009
          : 138
          : 4
          : 628-644
          Article
          10.1016/j.cell.2009.08.005
          4099469
          19703392
          ca869f19-5881-4809-9b02-0164568fde8e
          © 2009

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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