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      Experimental Nephropathy Induced by Haemophilus parainfluenzae Antigens

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          Background: We have demonstrated that outer membrane antigens of Haemophilus parainfluenzae (OMHP) are potentially involved in IgA nephropathy (IgAN). In this study, we established an experimental model of IgAN using OMHP antigens and investigated the nephritogenicity of OMHP antigens. Methods: One hundred and twenty C3H/HeN mice were administered OMHP antigens orally (PO group) or intraperitoneally (IP group). Mice were sacrificed at 10, 20, 30, 40, and 50 weeks of age to examine sequential glomerular changes and to measure levels of IgG, IgA, and IgM antibody against OMHP by ELISA. Results: Glomerular deposition of IgA and increases in the amount of mesangial matrix were observed in the PO group and the IP group from 40 and 30 weeks of age, respectively. Mice in both groups showed glomerular deposition of OMHP antigens from 30 or 40 weeks of age. Levels of IgA antibodies against OMHP were significantly increased in the PO and IP groups compared with controls. There was a significant correlation between mesangial proliferation and glomerular deposition of IgA. Conclusions: Administration of OMHP antigens to mice may induce glomerular deposition of IgA and mesangial proliferation, resembling the changes seen in IgAN, with increases in IgA antibodies against OMHP antigens. This is the first use of OMHP antigens to establish an active model of IgAN.

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          • Record: found
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          The role of nasopharyngeal lymphoid tissue.

          Nasal-associated lymphoid tissue (NALT), which comprises paired lymphoid organs in the nasopharynx of rodents, is the principal mucosal lymphoid tissue of the respiratory tract. As described in this review, NALT bears certain similarities to the Peyer's patches of the intestine but the two differ remarkably in morphology, lymphoid migration patterns and the binding properties of their high endothelial venules (HEV).
            • Record: found
            • Abstract: found
            • Article: not found

            Regional specialization in the mucosal immune system: what happens in the microcompartments?

            Mucosal immunity is an important arm of the immune system because it operates in tissues involved in everyday infectious defence as well as in tolerance against innocuous environmental and dietary antigens. Here, Per Brandtzaeg and colleagues discuss compartmentalized regulation of mucosal B cells and mechanisms that might explain the strikingly regionalized effector disparity of the human mucosal immune system.
              • Record: found
              • Abstract: not found
              • Article: not found

              Haemophilus parainfluenzae antigen and antibody in renal biopsy samples and serum of patients with IgA nephropathy


                Author and article information

                S. Karger AG
                March 2002
                25 February 2002
                : 90
                : 3
                : 320-327
                aDepartment of Clinical and Laboratory Medicine, Fukui Medical University, Fukui; bDepartment of Medicine (II), Niigata University School of Medicine, Niigata, Japan
                49068 Nephron 2002;90:320–327
                © 2002 S. Karger AG, Basel

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                Figures: 6, Tables: 1, References: 45, Pages: 8
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