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      Spin Trapping: ESR parameters of spin adducts 1474 1528V

      Free Radical Biology and Medicine

      Elsevier BV

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          Free-radical chemistry of cigarette smoke and its toxicological implications.

           D Church,  W A Pryor (1985)
          Cigarette smoke contains two very different populations of free radicals, one in the tar and one in the gas phase. The tar phase contains several relatively stable free radicals; we have identified the principal radical as a quinone/hydroquinone (Q/QH2) complex held in the tarry matrix. We suggest that this Q/QH2 polymer is an active redox system that is capable of reducing molecular oxygen to produce superoxide, eventually leading to hydrogen peroxide and hydroxyl radicals. In addition, we have shown that the principal radical in tar reacts with DNA in vitro, possibly by covalent binding. The gas phase of cigarette smoke contains small oxygen- and carbon-centered radicals that are much more reactive than are the tar-phase radicals. These gas-phase radicals do not arise in the flame, but rather are produced in a steady state by the oxidation of NO to NO2, which then reacts with reactive species in smoke such as isoprene. We suggest that these radicals and the metastable products derived from these radical reactions may be responsible for the inactivation of alpha 1-proteinase inhibitor by fresh smoke. Cigarette smoke oxidizes thiols to disulfides; we suggest the active oxidants are NO and NO2. The effects of smoke on lipid peroxidation are complex, and this is discussed. We also discuss the toxicological implications for the radicals in smoke in terms of a number of radical-mediated disease processes, including emphysema and cancer.
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            Spin trapping of superoxide and hydroxyl radical: practical aspects.

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              Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals

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                Author and article information

                Journal
                Free Radical Biology and Medicine
                Free Radical Biology and Medicine
                Elsevier BV
                08915849
                January 1987
                January 1987
                : 3
                : 4
                : 259-303
                Article
                10.1016/S0891-5849(87)80033-3
                © 1987

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