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      Resorption: part 1. Pathology, classification and aetiology

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      BDJ

      Springer Nature

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          Most cited references 108

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          Osteoclast differentiation and activation.

          Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic lineage that develop and adhere to bone matrix, then secrete acid and lytic enzymes that degrade it in a specialized, extracellular compartment. Discovery of the RANK signalling pathway in the osteoclast has provided insight into the mechanisms of osteoclastogenesis and activation of bone resorption, and how hormonal signals impact bone structure and mass. Further study of this pathway is providing the molecular basis for developing therapeutics to treat osteoporosis and other diseases of bone loss.
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            Integrins Versatility modulation and signaling in cell adhesion

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              Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

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                Author and article information

                Journal
                BDJ
                Br Dent J
                Springer Nature
                0007-0610
                1476-5373
                May 10 2013
                May 10 2013
                : 214
                : 9
                : 439-451
                Article
                10.1038/sj.bdj.2013.431
                © 2013

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