6
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Recent advances in adjunctive therapy for epilepsy: focus on sodium channel blockers as third-generation antiepileptic drugs.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Voltage-gated sodium channel blockers like phenytoin and carbamazepine have long been used in the treatment of epilepsy. Brain sodium channels continue to be an important target of many newer second-generation (fosphenytoin, oxcarbazepine, lamotrigine, felbamate, topiramate, zonisamide) and third-generation (eslicarbazepine, brivaracetam, carisbamate, fluorofelbamate, elpetrigine, lacosamide, rufinamide, safinamide, vinpocetine) antiepileptic drugs (AEDs). Some of the newer drugs show either state-dependent antiepileptic action or sodium channel subtype selectivity, although most agents do not differentiate between these channel subtypes. The present review highlights the preclinical and clinical efficacy, pharmacokinetics, drug interactions and adverse event profiles. It also addresses AED selection of sodium channel blockers that constitutes the third generation of AEDs.

          Related collections

          Author and article information

          Journal
          Drugs Today
          Drugs of today (Barcelona, Spain : 1998)
          Prous Science
          1699-3993
          1699-3993
          Apr 2010
          : 46
          : 4
          Affiliations
          [1 ] Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi, India. dvohra@jamiahamdard.ac.in
          Article
          1445795
          10.1358/dot.2010.46.4.1445795
          20502724
          cab3d012-5380-4061-a039-efe005c400db
          History

          Comments

          Comment on this article