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      Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor.

      Nature
      Amino Acid Sequence, Animals, Blotting, Northern, Blotting, Southern, Chemotaxis, Chick Embryo, Cloning, Molecular, DNA, Mice, Mice, Nude, Molecular Sequence Data, Neovascularization, Pathologic, Platelet-Derived Growth Factor, physiology, Tumor Cells, Cultured

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          Abstract

          Cloning and sequencing of the complementary DNA for platelet-derived endothelial cell growth factor indicates that it is a novel factor distinct from previously characterized proteins. The factor, a protein with a relative molecular mass of about 45,000, stimulates endothelial cell growth and chemotaxis in vitro and angiogenesis in vivo.

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