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      Resistin Levels in Lupus and Associations with Disease-Specific Measures, Insulin Resistance, and Coronary Calcification

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          Abstract

          Objective

          To evaluate levels of resistin in female subjects with systemic lupus erythematosus (SLE) compared to age and race-matched controls and to determine the relationship between resistin and systemic inflammation, disease measures, and coronary artery calcification(CAC).

          Methods

          Resistin levels were measured on stored samples from 159 female SLE subjects and 70 age and race-matched controls as an extension of a previous cross-sectional study. Spearman correlations and multivariable regressions were used to examine whether resistin levels were associated with SLE, disease-specific and inflammatory markers, insulin resistance, and CAC.

          Results

          In a multivariable linear regression model, a diagnosis of SLE was significantly associated with higher resistin levels independent of age, race, renal function, body mass index (BMI), high-sensitivity CRP (hsCRP), hypertension, diabetes and steroid use. In SLE, resistin levels positively correlated with SLICC Damage Index, GFR, hsCRP, ESR, homocysteine, and disease duration (all p<0.03). Resistin level did not correlate with markers of insulin resistance or body adiposity, including homeostatic model assessment or BMI. Resistin levels were significantly elevated in SLE cases with CAC compared to cases without CAC (16.58 v. 13.10 ng/ml, p= 0.04). However, in multivariate logistic regression, the association not present after adjustment for age, race, and GFR.

          Conclusion

          SLE was independently associated with higher resistin levels. Among SLE, higher resistin correlated positively with renal dysfunction, inflammatory markers, and disease damage but not with insulin resistance or BMI. SLE cases with CAC had higher resistin levels than cases without CAC, however, this relationship was dependent on other established risk factors.

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          Author and article information

          Journal
          7501984
          5243
          J Rheumatol
          J. Rheumatol.
          The Journal of rheumatology
          0315-162X
          18 November 2017
          01 September 2011
          November 2011
          27 November 2017
          : 38
          : 11
          : 2369-2375
          Affiliations
          [1 ]Division of Rheumatology, Department of Medicine, University of Pennsylvania
          [2 ]Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania
          [3 ]Division of Endocrinology, Diabetes & Metabolism, University of Pennsylvania
          Author notes
          Address reprint requests to: Dr. J.M. Von Feldt, MD, MSEd, PVAMC, 3900 Woodland Ave #A948 Philadelphia, PA 19104, USA, Office: (215) 823-5251 Fax: 215-823-5276, vonfeldt@ 123456upenn.edu
          Article
          PMC5702914 PMC5702914 5702914 nihpa921172
          10.3899/jrheum.110237
          5702914
          21885493
          cac2f35d-5360-434e-8ee1-7575703129a4
          History
          Categories
          Article

          resistin,systemic lupus erythematosus,atherosclerosis,insulin resistance

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