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      The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

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          The National Institute on Aging and the Alzheimer's Association charged a workgroup with the task of revising the 1984 criteria for Alzheimer's disease (AD) dementia. The workgroup sought to ensure that the revised criteria would be flexible enough to be used by both general healthcare providers without access to neuropsychological testing, advanced imaging, and cerebrospinal fluid measures, and specialized investigators involved in research or in clinical trial studies who would have these tools available. We present criteria for all-cause dementia and for AD dementia. We retained the general framework of probable AD dementia from the 1984 criteria. On the basis of the past 27 years of experience, we made several changes in the clinical criteria for the diagnosis. We also retained the term possible AD dementia, but redefined it in a manner more focused than before. Biomarker evidence was also integrated into the diagnostic formulations for probable and possible AD dementia for use in research settings. The core clinical criteria for AD dementia will continue to be the cornerstone of the diagnosis in clinical practice, but biomarker evidence is expected to enhance the pathophysiological specificity of the diagnosis of AD dementia. Much work lies ahead for validating the biomarker diagnosis of AD dementia. Copyright © 2011. Published by Elsevier Inc.

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          Alzheimer's & Dementia
          Alzheimer's & Dementia
          Elsevier BV
          May 2011
          May 2011
          April 22 2011
          : 7
          : 3
          : 263-269
          [1 ]Department of Neurology; Johns Hopkins University School of Medicine; Baltimore MD USA
          [2 ]Zanvyl Krieger Mind/Brain Institute; Johns Hopkins University; Baltimore MD USA
          [3 ]Department of Neurology; Mayo Clinic; Rochester MN USA
          [4 ]Department of Neurology; McGill University School of Medicine; Montreal QC Canada
          [5 ]Bloomfield Centre for Research in Aging; Lady Davis Institute; Montreal QC Canada
          [6 ]Department of Neurology; Massachusetts General Hospital; Harvard Medical School; Boston MA USA
          [7 ]Department of Radiology; Mayo Clinic; Rochester MN USA
          [8 ]Department of Neurology; University of California; Irvine CA USA
          [9 ]Department of Neurobiology and Behavior; University of California; Irvine CA USA
          [10 ]Alzheimer Disease Research Center; University of California; Irvine CA USA
          [11 ]Department of Psychiatry; University of Pittsburgh School of Medicine; Pittsburgh PA USA
          [12 ]National Institute of Neurological Disorders and Stroke; Bethesda MD USA
          [13 ]Taub Institute for Research on Alzheimer's Disease and the Aging Brain; Columbia University Medical Center; New York NY USA
          [14 ]Gertrude H. Sergievsky Center; Columbia University Medical Center; New York NY USA
          [15 ]Department of Neurology; Columbia University Medical Center; New York NY USA
          [16 ]Eli Lilly and Company; Indianapolis IN USA
          [17 ]Department of Neurology; Washington University School of Medicine; St. Louis MO USA
          [18 ]Dementia Research Centre; Department of Neurodegeneration; UCL Institute of Neurology; University College London; Queen Square London United Kingdom
          [19 ]Department of Neurology and Alzheimer Center; VU University Medical Center; Amsterdam The Netherlands
          [20 ]Alzheimer's Association; Chicago IL USA
          [21 ]Department of Psychiatry; Northwestern Feinberg School of Medicine; Chicago IL USA
          [22 ]Department of Neurology; Northwestern Feinberg School of Medicine; Chicago IL USA
          [23 ]Alzheimer's Disease Centers Program; National Institute on Aging; Bethesda MD USA
          © 2011




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