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      Effects of Streptozotocin on Liver Composition and Blood Glucose, Ketone Bodies and Insulin in the Fed and Fasted Male Rat

      research-article
      ,
      Hormone Research in Paediatrics
      S. Karger AG
      Streptozotocin, Diabetes, Glycemia, Ketonemia, Insulinemia, Liver, Acetyl-CoA, Citric acid

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          Abstract

          Three days after a single injection of streptozotocin rats showed hyperglycemia, hyperketonemia and hypoinsulinemia. Body and liver weights were reduced and the concentration of DNA-P, phospholipid-P, proteins and acetyl-CoA in the liver was augmented, while the concentration of glycogen and citric acid in these animals compared with the controls which did not receive the drug was decreased. After 48 h starvation, blood glucose remained higher in the streptozotocin-treated animals, while circulating ketones and insulin were not different from those in the controls. With the exception of body and liver weights, which were lower, and of liver DNA-P, which was higher than when fed, neither of the other parameters studied in the streptozotocin treated animals changed with fasting, while the response in the controls was normal. The incapacity of increasing the postprandial insulin secretion in these animals may contribute to the metabolic alterations found in the fed state.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1974
          1974
          21 November 2008
          : 5
          : 1
          : 29-38
          Affiliations
          Department of Experimental Endocrinology, G. Marañón Institute, CSIC, and Academic Chair for General Physiology, Faculty of Sciences, University of Barcelona, Barcelona
          Article
          178616 Horm Res 1974;5:29–38
          10.1159/000178616
          4272545
          cad44cf7-6492-4a3b-9c1e-923f1995ddea
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Page count
          Pages: 10
          Categories
          Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Glycemia,Streptozotocin,Diabetes,Ketonemia,Insulinemia,Liver,Acetyl-CoA,Citric acid

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