Overdiagnosis of Clostridium difficile Infection in the Molecular Test Era.

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Abstract

Clostridium difficile is a major cause of health care-associated infection, but disagreement between diagnostic tests is an ongoing barrier to clinical decision making and public health reporting. Molecular tests are increasingly used to diagnose C difficile infection (CDI), but many molecular test-positive patients lack toxins that historically defined disease, making it unclear if they need treatment.

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Journal

Journal ID (iso-abbrev): JAMA Intern Med

Title: JAMA internal medicine

ISSN (Electronic): 2168-6114

ISSN (Print): 2168-6106

Publication date (Electronic): Nov 2015

Volume: 175

Issue: 11

Affiliations

[1 ] Department of Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento2Division of Infectious Diseases, Department of Internal Medicine, University of California Davis School of Medicine, Sacramento.

[2 ] Department of Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento.

[3 ] Department of Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento3Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor.

[4 ] Center for Healthcare Policy and Research, University of California Davis, Sacramento.

[5 ] Department of Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento5Yolo County Health Department, Woodland, California.

[6 ] Division of Infectious Diseases, Department of Internal Medicine, University of California Davis School of Medicine, Sacramento.

[7 ] Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York7Department of Clinical Laboratory, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

[8 ] Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York8Weill Medical College of Cornell University, New York, New York.

[9 ] Division of Biostatistics, Department of Public Health Sciences, University of California Davis School of Medicine, Sacramento.

[10 ] Center for Healthcare Policy and Research, University of California Davis, Sacramento10Division of General Medicine, Department of Internal Medicine, University of California Davis School of Medicine, Sacramento11Division of General Pediatrics, Department.

[11 ] Department of Emergency Medicine, University of California Davis School of Medicine, Sacramento.

[12 ] Division of Infectious Diseases, Department of Internal Medicine, University of California Davis School of Medicine, Sacramento13Department of Medical Microbiology and Immunology, University of California Davis School of Medicine, Sacramento.

Article

Publisher Item ID: 2434732 Mid ID: NIHMS799631

DOI: 10.1001/jamainternmed.2015.4114

PubMed ID: 26348734

SO-VID: cadfc0e3-edd7-480b-b1d5-7214a4b404f4

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