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      COVID-19 Associated Multisystem Inflammatory Syndrome in Children Presenting as Acute Necrotizing Pancreatitis with Walled-off Pancreatic Necrosis (WOPN)

      case-report

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          ABSTRACT

          Aim and objective

          To highlight the importance of looking for multisystem inflammatory syndrome in children (MIS-C) as an etiology of pancreatitis in children.

          Background

          MIS-C is a newly recognized, potentially serious illness in children related to COVID-19. MIS-C has varied symptoms that affect several organ systems in body. Many children have symptoms resembling Kawasaki disease. some children have signs of excessive blood clotting, gastrointestinal symptoms, kidney injury, or neurological symptoms. To date, very few cases have been reported with acute pancreatitis with SARS CoV-2 infection in children and only two cases with subsequent inflammatory syndrome.

          Case description

          A 12-year old male child with severe necrotizing pancreatitis managed with IVIg and I/V methylprednisolone, which later on developed walled-off pancreatic necrosis (WOPN) required surgical intervention.

          Conclusion

          It is important to look for etiology of pancreatitis and in present era MIS-C is important cause. Clinicians should always search for this etiology as management is entirely different from other causes of pancreatitis.

          Clinical significance

          We describe first case of necrotizing pancreatitis with walled-off pancreatic necrosis requiring surgical intervention associated with MIS-C. Management required IVIg and/ or steroids which is entirely different from pancreatitis associated with other etiologies.

          How to cite this article

          Vijay P, Gupta RK, Madaan A, et al. COVID-19 Associated Multisystem Inflammatory Syndrome in Children Presenting as Acute Necrotizing Pancreatitis with Walled-off Pancreatic Necrosis (WOPN). Pediatr Inf Dis 2023;5(2):60-62.

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          Most cited references11

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          Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus

          The recent emergence of Wuhan coronavirus (2019-nCoV) puts the world on alert. 2019-nCoV is reminiscent of the SARS-CoV outbreak in 2002 to 2003. Our decade-long structural studies on the receptor recognition by SARS-CoV have identified key interactions between SARS-CoV spike protein and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of SARS-CoV. One of the goals of SARS-CoV research was to build an atomic-level iterative framework of virus-receptor interactions to facilitate epidemic surveillance, predict species-specific receptor usage, and identify potential animal hosts and animal models of viruses. Based on the sequence of 2019-nCoV spike protein, we apply this predictive framework to provide novel insights into the receptor usage and likely host range of 2019-nCoV. This study provides a robust test of this reiterative framework, providing the basic, translational, and public health research communities with predictive insights that may help study and battle this novel 2019-nCoV.
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            Epidemiological Characteristics of 2143 Pediatric Patients With 2019 Coronavirus Disease in China

            To identify the epidemiological characteristics and transmission patterns of pediatric patients with the 2019 novel coronavirus disease (COVID-19) in China.
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              Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus.

              The Atlanta classification of acute pancreatitis enabled standardised reporting of research and aided communication between clinicians. Deficiencies identified and improved understanding of the disease make a revision necessary. A web-based consultation was undertaken in 2007 to ensure wide participation of pancreatologists. After an initial meeting, the Working Group sent a draft document to 11 national and international pancreatic associations. This working draft was forwarded to all members. Revisions were made in response to comments, and the web-based consultation was repeated three times. The final consensus was reviewed, and only statements based on published evidence were retained. The revised classification of acute pancreatitis identified two phases of the disease: early and late. Severity is classified as mild, moderate or severe. Mild acute pancreatitis, the most common form, has no organ failure, local or systemic complications and usually resolves in the first week. Moderately severe acute pancreatitis is defined by the presence of transient organ failure, local complications or exacerbation of co-morbid disease. Severe acute pancreatitis is defined by persistent organ failure, that is, organ failure >48 h. Local complications are peripancreatic fluid collections, pancreatic and peripancreatic necrosis (sterile or infected), pseudocyst and walled-off necrosis (sterile or infected). We present a standardised template for reporting CT images. This international, web-based consensus provides clear definitions to classify acute pancreatitis using easily identified clinical and radiologic criteria. The wide consultation among pancreatologists to reach this consensus should encourage widespread adoption.

                Author and article information

                Contributors
                Journal
                PID
                Pediatric Infectious Disease
                PID
                Jaypee Brothers Medical Publishers
                2582-4988
                April-June 2023
                : 5
                : 2
                : 60-62
                Affiliations
                [1-4 ]Department of Pediatrics, SMS Medical College, Jaipur, Rajasthan, India
                Author notes
                Raj Kumar Gupta, Department of Pediatrics, SMS Medical college, Jaipur, Rajasthan, India, Phone: +91 9414054040, e-mail: rkguptadr@ 123456hotmail.com
                Article
                10.5005/jp-journals-10081-1340
                caf4c8a5-33a7-4cbc-9640-fa35364d007e
                Copyright © 2023; The Author(s).

                © The Author(s). 2023 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and non-commercial reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 19 September 2021
                : 11 November 2021
                : 30 June 2023
                Categories
                CASE REPORT
                Custom metadata
                pid-05-060.pdf

                Pediatrics
                Necrotizing pancreatitis,MIS-C,Walled-off pancreatic necrosis
                Pediatrics
                Necrotizing pancreatitis, MIS-C, Walled-off pancreatic necrosis

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