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      • Record: found
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      • Article: found

      Effect of Calcium Channel Blockers on Intraocular Pressure

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          Abstract

          We determined the effects of either topical or systemic calcium channel antagonists on rabbit intraocular pressure (IOP). Topical nifedipine, verapamil or diltiazem had no significant effect on IOP. Intravenous verapamil and nifedipine caused statistically significant reductions in IOP between 2 and 6 h after administration; the nifedipine response followed an increase in IOP at 30 min. Diltiazem, given 3 times daily for 3 days, caused no pressure change. In the rabbit, therefore, calcium channel antagonists have no effect when given topically, but do reduce IOP when given systemically.

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          Author and article information

          Journal
          Journal ID (publisher-id): ORE
          Journal ID (nlm-ta): Ophthalmic Res
          Journal ID (doi): 10.1159/issn.0030-3747
          Title: Ophthalmic Research
          Publisher: S. Karger AG
          ISSN (Print): 0030-3747
          ISSN (Electronic): 1423-0259
          Publication date Subscription-year: 1990
          Publication date (Print): 1990
          Publication date (Electronic): 10 December 2009
          Volume: 22
          Issue: 6
          Pages: 337-341
          Affiliations
          Departments of aOphthalmology and bPhysiology and Endocrinology, Medical College of Georgia, Augusta, Ga., USA
          Article
          Publisher ID: 267044 Other ID: Ophthalmic Res 1990;22:337–341
          DOI: 10.1159/000267044
          PubMed ID: 2089345
          SO-VID: caf8be20-0a03-4df2-9e4f-d2f5e6e49e95
          Copyright © © 1990 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 27 February 1990
          Date accepted : 02 May 1990
          Page count
          Pages: 5
          Categories
          Subject: Paper

          ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
          Keywords: Diltiazem,Intraocular pressure,Verapamil,Calcium channel blockers, topical/intravenous administration,Rabbits,Nifedipine
          Data availability:
          ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
          Keywords: Diltiazem, Intraocular pressure, Verapamil, Calcium channel blockers, topical/intravenous administration, Rabbits, Nifedipine

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