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      Molecular mechanisms of glioma invasiveness: the role of proteases.

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      Nature reviews. Cancer
      Springer Science and Business Media LLC

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          Abstract

          The invasive nature of brain-tumour cells makes an important contribution to the ineffectiveness of current treatment modalities, as the remaining tumour cells inevitably infiltrate the surrounding normal brain tissue, which leads to tumour recurrence. Such local invasion remains an important cause of mortality and underscores the need to understand in more detail the mechanisms of tumour invasiveness. Several proteases influence the malignant characteristics of gliomas--could their inhibition prove to be a useful therapeutic strategy?

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          Author and article information

          Journal
          Nat Rev Cancer
          Nature reviews. Cancer
          Springer Science and Business Media LLC
          1474-175X
          1474-175X
          Jul 2003
          : 3
          : 7
          Affiliations
          [1 ] Program of Cancer Biology, Department of Neurosurgery, University of Illinois College of Medicine-Peoria, 1 Illini Drive, Peoria, Illinois 61656, USA. jsrao@uic.edu
          Article
          nrc1121
          10.1038/nrc1121
          12835669
          cb13afa6-2100-4801-b05c-a5851ac75226
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