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      [Research on hemostatic constituents in carbonized Schizonepeta tenuifolia Brig].

      Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

      Whole Blood Coagulation Time, Drugs, Chinese Herbal, pharmacology, toxicity, Female, Hemostatics, Animals, Male, Mice, Mice, Inbred ICR, Rabbits

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          Abstract

          It has been shown that the fatsoluble extract SeE from carbonized Schizonepeta tenuifolia has an obvious hemostatic action. In a given range of dose there is a significant linear correlation between the logarithms of its doses and the reciprocal of the bleeding and coagulating times in mice. Obvious hemostatic action was observed after mice had been administered in ip and po respectively for 0.5h and 1h. The hemostatic time of the former was 6h and the latter 12h. The LD50 of StE in po was 2.652 +/- 0.286 g/kg, while in ip 1.945 4/- 0.207 g/kg.

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          8011107

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