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      Urinary Excretion of Tamm-Horsfall Protein and Epidermal Growth Factor in Chronic Nephropathy

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          Abstract

          Tamm-Horsfall protein (THP) and epidermal growth factor (EGF) are both synthesized by tubular cells in the distal part of the nephron and excreted with the urine. The present study examines the urinary excretion rates of the two peptides in relation to functional tubular markers in patients with chronic nephropathy. Four groups of patients with moderate to severely reduced renal function were studied: glomerulonephritis (n = 10), diabetic nephropathy (n = 11), tubulointerstitial nephropathy (n = 13), and polycystic kidney disease (n = 8). The renal function was evaluated by glomerular filtration rate (GFR) as an indicator for the general renal function, lithium clearance (C<sub>Li</sub>) as an indicator for proximal tubular function, and absolute distal reabsorption of sodium (ADR<sub>Na</sub>) as an indicator for distal tubular function. The excretion rate of EGF was rather closely correlated with GFR, C<sub>Li</sub> and ADR<sub>Na</sub> (Spearman coefficients of variation 0.88, 0.69, and 0.74, respectively). The correlations between the excretion rate of THP and GFR, C<sub>Li</sub> and ADR<sub>Na</sub> were weaker (Spearman coefficients of variation 0.68, 0.42, and 0.44). When the effect of GFR had been accounted for by multiple variance analyses, the excretion rates of the two peptides were still associated with ADR<sub>Na</sub> but not with C<sub>Li</sub>. In conclusion, the urinary excretion rates of especially EGF but also those of THP were correlated with renal function and distal tubular reabsorption of sodium in patients with chronic nephropathy.

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          Most cited references 5

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          Human epidermal growth factor: renal production and absence from plasma

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            Tubular secretion of Tamm-Horsfall protein in type 1 (insulin-dependent) diabetes mellitus using a simplified enzyme linked immunoassay

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              Human epidermal growth factor—on molecular forms present in urine and blood

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                Author and article information

                Journal
                NEF
                Nephron
                10.1159/issn.1660-8151
                Nephron
                S. Karger AG
                1660-8151
                2235-3186
                1998
                June 1998
                27 May 1998
                : 79
                : 2
                : 167-172
                Affiliations
                aDepartment of Internal Medicine, University Hospital of Lund, Sweden; b Department of Clinical Biochemistry, KH University Hospital of Aarhus, c Department of Nephrology, Herlev Hospital, University of Copenhagen, d Department of Medical Physiology, Division of Pathophysiology, University of Copenhagen, e Institute of Medical Anatomy, University of Copenhagen, Denmark
                Article
                45020 Nephron 1998;79:167–172
                10.1159/000045020
                9647496
                © 1998 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 2, References: 31, Pages: 6
                Product
                Self URI (application/pdf): https://www.karger.com/Article/Pdf/45020
                Categories
                Original Paper

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