Synthesis and preclinical evaluation of [¹⁸F]FCHC for neuroimaging of fatty acid amide hydrolase.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Fatty acid amide hydrolase (FAAH), a catabolic enzyme which regulates lipid transmitters in the endocannabinoid system, is an avidly sought therapeutic and positron emission tomography (PET) imaging target for studies involving addiction and neurological disorders. We report the synthesis of a new fluorine-18-labeled FAAH inhibitor, trans-3-(4, 5-dihydrooxazol-2-yl)phenyl-4-[(18)F]fluorocyclohexylcarbamate ([(18)F]FCHC), and its evaluation in rat brain.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Mol Imaging Biol

Title: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging

Publisher: Springer Nature

ISSN (Electronic): 1860-2002

ISSN (Print): 1536-1632

Publication date (Electronic): Apr 2015

Volume: 17

Issue: 2

Affiliations

[1 ] Division of Nuclear Medicine and Molecular Imaging, Center for Advanced Medical Imaging Sciences, Massachusetts General Hospital, and Department of Radiology, Harvard Medical School, Boston, MA, USA.

Article

DOI: 10.1007/s11307-014-0789-1

PubMed ID: 25273322

SO-VID: cb4ab359-717f-40cc-9256-9fe86b355eed

History

Data availability:

Comments

Comment on this article

scite_

Cited by 4

See all cited by