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      Selective loss of beta 2-microglobulin mRNA in human colon carcinoma

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      The Journal of Experimental Medicine
      The Rockefeller University Press

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          Abstract

          Expression of MHC class I antigens requires the intracellular assembly of HLA-A,B,C H chains and beta 2-microglobulin (beta 2m). We have investigated the expression of free H chain, beta 2m, and their mRNAs in tissue sections of colon carcinomas that were defective for the native two-chain molecule. In all of these tumors, beta 2m protein and mRNA were found to be completely absent from the neoplastic cells, whereas free H chains and their respective mRNAs were present in abundance in the tumor cell cytoplasm. The selective abrogation of beta 2m expression represents a unique mechanism leading to a complete loss of class I antigen surface expression in vivo.

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          Author and article information

          Journal
          J Exp Med
          The Journal of Experimental Medicine
          The Rockefeller University Press
          0022-1007
          1540-9538
          1 January 1989
          : 169
          : 1
          : 309-314
          Article
          89080493
          2189171
          2642530
          cb569d33-2e33-41fe-b1ec-c1ebd616b455
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          Medicine
          Medicine

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