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      Graphene quantum dot-decorated mesoporous silica nanoparticles for high aspirin loading capacity and its pH-triggered release

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          Abstract

          In this paper, fluorescent graphene quantum dots (GQDs) grafted onto the surface of mesoporous silica nanoparticle (MSN) vehicles were prepared and characterized.

          Abstract

          In this paper, fluorescent graphene quantum dots (GQDs) grafted onto the surface of mesoporous silica nanoparticle (MSN) vehicles were prepared and characterized. The as-prepared graphene quantum dot-decorated mesoporous silica nanoparticles (GQD-MSNs) exhibited excellent luminescence properties in vitro. Interestingly, compared to pure MSNs, the specific surface area and pore volume of GQD-MSNs increased by 59.1% and 48.9%, respectively. These optimized features granted GQD-MSNs a high aspirin loading capacity, which was twice as much as that of pure MSN. Moreover, most of the aspirin encapsulated (95.15%) could be released from the surface of GQD-MSNs under acidic conditions (pH 2.5) within 33 h.

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          Most cited references 27

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          Is Open Access

          Electric Field Effect in Atomically Thin Carbon Films

          We report a naturally-occurring two-dimensional material (graphene that can be viewed as a gigantic flat fullerene molecule, describe its electronic properties and demonstrate all-metallic field-effect transistor, which uniquely exhibits ballistic transport at submicron distances even at room temperature.
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            Probing the Cytotoxicity of Semiconductor Quantum Dots

            With their bright, photostable fluorescence, semiconductor quantum dots show promise as alternatives to organic dyes for biological labeling. Questions about their potential cytotoxicity, however, remain unanswered. While cytotoxicity of bulk cadmium selenide (CdSe) is well documented, a number of groups have suggested that CdSe QDs are cytocompatible, at least with some immortalized cell lines. Using primary hepatocytes as a liver model, we found that CdSe-core QDs were indeed acutely toxic under certain conditions. Specifically, we found that the cytotoxicity of QDs was modulated by processing parameters during synthesis, exposure to ultraviolet light, and surface coatings. Our data further suggests that cytotoxicity correlates with the liberation of free Cd2+ ions due to deterioration of the CdSe lattice. When appropriately coated, CdSe-core QDs can be rendered non-toxic and used to track cell migration and reorganization in vitro. Our results inform design criteria for the use of QDs in vitro and especially in vivo where deterioration over time may occur.
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              Is Open Access

              Nano-Graphene Oxide for Cellular Imaging and Drug Delivery

              Two-dimensional graphene offers interesting electronic, thermal and mechanical properties that are currently explored for advanced electronics, membranes and composites. Here we synthesize and explore the biological application of nano-graphene oxide NGO, single-layer graphene oxide sheets down to a few nanometers in lateral width. We develop functionalization chemistry to impart solubility and compatibility of NGO in biological environments. We obtain size separated pegylated NGO sheets that are soluble in buffers and serum without agglomeration. The NGO sheets are found to be photoluminescent in the visible and infrared regions. The intrinsic photoluminescence of NGO is used for live cell imaging in the near-infrared with little background. We found that simple physisorption via pi-stacking can be used for loading doxorubicin, a widely used cancer drug onto NGO functionalized with antibody for selective cancer cell killing in vitro. Owing to the small size, intrinsic optical properties, large specific surface area,low cost, and useful non-covalent interactions with aromatic drug molecules, NGO is a promising new material for biological and medical applications.
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                Author and article information

                Journal
                AMNECT
                Analytical Methods
                Anal. Methods
                Royal Society of Chemistry (RSC)
                1759-9660
                1759-9679
                2016
                2016
                : 8
                : 12
                : 2561-2567
                Affiliations
                [1 ]Department of Chemistry
                [2 ]College of Science
                [3 ]Huazhong Agricultural University
                [4 ]Wuhan 430070
                [5 ]P. R. China
                [6 ]State Key Laboratory of Agricultural Microbiology
                Article
                10.1039/C5AY03176A
                © 2016
                Product
                Self URI (article page): http://xlink.rsc.org/?DOI=C5AY03176A

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