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The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions
S. S. Merchant ,
S. E. Prochnik ,
O. Vallon ,
E. H. Harris ,
S. J. Karpowicz ,
G. B. Witman ,
A. Terry ,
A. Salamov ,
L. K. Fritz-Laylin ,
L. Marechal-Drouard ,
W. F. Marshall ,
L.-H. Qu ,
D. R. Nelson ,
A. A. Sanderfoot ,
M. H. Spalding ,
V. V. Kapitonov ,
Q. Ren ,
P. Ferris ,
E. Lindquist ,
H. Shapiro ,
S. M. Lucas ,
J. Grimwood ,
J. Schmutz ,
P. Cardol ,
H. Cerutti ,
G. Chanfreau ,
C.-L. Chen ,
V. Cognat ,
M. T. Croft ,
R. Dent ,
S. Dutcher ,
E. Fernandez ,
H. Fukuzawa ,
D. Gonzalez-Ballester ,
D. Gonzalez-Halphen ,
A. Hallmann ,
M. Hanikenne ,
M. Hippler ,
W. Inwood ,
K. Jabbari ,
M. Kalanon ,
R. Kuras ,
P. A. Lefebvre ,
S. D. Lemaire ,
A. V. Lobanov ,
M. Lohr ,
A. Manuell ,
I. Meier ,
L. Mets ,
M. Mittag ,
T. Mittelmeier ,
J. V. Moroney ,
J. Moseley ,
C. Napoli ,
A. M. Nedelcu ,
K. Niyogi ,
S. V. Novoselov ,
I. T. Paulsen ,
G. Pazour ,
S. Purton ,
J.-P. Ral ,
D. M. Riano-Pachon ,
W. Riekhof ,
L. Rymarquis ,
M. Schroda ,
D. Stern ,
J. Umen ,
R. Willows ,
N. Wilson ,
S. L. Zimmer ,
J. Allmer ,
J. Balk ,
K. Bisova ,
C.-J. Chen ,
M. Elias ,
K. Gendler ,
C. Hauser ,
M. R. Lamb ,
H. Ledford ,
J. C. Long ,
J. Minagawa ,
M. D. Page ,
J. Pan ,
W. Pootakham ,
S. Roje ,
A. Rose ,
E. Stahlberg ,
A. M. Terauchi ,
P. Yang ,
S. Ball ,
C. Bowler ,
C. L. Dieckmann ,
V. N. Gladyshev ,
P. Green ,
R. Jorgensen ,
S. Mayfield ,
B. Mueller-Roeber ,
S. Rajamani ,
R. T. Sayre ,
P. Brokstein ,
I. Dubchak ,
D. Goodstein ,
L. Hornick ,
Y. W. Huang ,
J. Jhaveri ,
Y. Luo ,
D. Martinez ,
W. C. A. Ngau ,
B. Otillar ,
A. Poliakov ,
A. Porter ,
L. Szajkowski ,
G. Werner ,
K. Zhou ,
I. V. Grigoriev ,
D. S. Rokhsar ,
A. R. Grossman
October 12 2007
October 12 2007
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Abstract
Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from
land plants over 1 billion years ago. It is a model system for studying chloroplast-based
photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella
(cilia), which were inherited from the common ancestor of plants and animals, but
lost in land plants. We sequenced the approximately 120-megabase nuclear genome of
Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding
uncharacterized proteins that are likely associated with the function and biogenesis
of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance
our understanding of the ancestral eukaryotic cell, reveal previously unknown genes
associated with photosynthetic and flagellar functions, and establish links between
ciliopathy and the composition and function of flagella.