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The state of regional therapy in the management of metastatic colorectal cancer to the liver.

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      Abstract

      Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality in the United States. Most colorectal cancer patients die from advanced disease, and two-thirds of CRC deaths are due to liver metastases. Liver resection provides the best curative option for patients with colorectal liver metastases (CRLM), yet only 20% of those patients are eligible for liver metastases resection for curative intent. Loco-regional treatment of CRLM may provide additional benefits in terms of down-staging for resection and prolonged hepatic disease control. This review focusses on hepatic arterial infusion, radioembolization and chemoembolization.

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      Affiliations
      [1 ] a Department of Medical Oncology , City of Hope National Medical Center , Duarte , CA , USA.
      Journal
      Expert Rev Anticancer Ther
      Expert review of anticancer therapy
      Informa UK Limited
      1744-8328
      1473-7140
      2016
      : 16
      : 2
      26652741 10.1586/14737140.2016.1129277

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