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      The distinct morphogenic states of Candida albicans.

      1 , ,
      Trends in microbiology
      Elsevier BV

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          Abstract

          The human fungal pathogen, Candida albicans can grow in at least three different morphologies: yeast, pseudohyphae and hyphae. Further morphological forms exist during colony switching, for example, opaque phase cells are oblong, rather than the oval shape of yeast cells. Pseudohyphae and hyphae are both elongated and sometimes there has been little attempt to distinguish between them, as both are "filamentous forms" of the fungus. We review here the differences between them that suggest that they are distinct morphological states. We argue that studies on "filamentous forms" should always include a formal analysis to determine whether the cells are hyphae or pseudohyphae and we suggest some simple experimental criteria that can be applied to achieve this.

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          Author and article information

          Journal
          Trends Microbiol
          Trends in microbiology
          Elsevier BV
          0966-842X
          0966-842X
          Jul 2004
          : 12
          : 7
          Affiliations
          [1 ] Sheffield University, Department of Molecular Biology and Biotechnology, Western Bank, Sheffield S10 2TN, UK. P.Sudbery@shef.ac.uk
          Article
          S0966842X04001180
          10.1016/j.tim.2004.05.008
          15223059
          cb931b87-7926-4d90-af74-8d9309dbe980
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