Genetic variations in CC chemokine receptors and hypertension.

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Abstract

CC-chemokine receptor 5 (CCR5) is a co-receptor for human immunodeficiency virus type 1 (HIV-1) infection. Homozygosity for a 32-base pair (bp) deletion (Delta32) in the CCR5 gene confers resistance to HIV-1. Previous studies found an increased prevalence of hypertension among CCR5-Delta32 homozygotes and among carriers of a polymorphism (CCR2-64I) found on the gene that codes a closely related chemokine receptor. The present study was carried out to verify these associations.

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Journal

Journal ID (iso-abbrev): Am. J. Hypertens.

Title: American journal of hypertension

Publisher: Elsevier BV

ISSN: 0895-7061

ISSN (Print): 0895-7061

Publication date (Electronic): Jan 2006

Volume: 19

Issue: 1

Affiliations

[1 ] Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH/DHHS, 6120 Executive Boulevard, Rm. 7082, MSC 7234, Rockville, MD 20852, USA.

Article

Publisher Item ID: S0895-7061(05)01087-3

DOI: 10.1016/j.amjhyper.2005.06.025

PubMed ID: 16461193

SO-VID: cb9d8fea-7420-4e52-882b-84c7f6180c36

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