Deferoxamine enhances the vascular response of bone regeneration in mandibular distraction osteogenesis.

Abstract

Bone regeneration during distraction osteogenesis is intricately associated with an enhanced vascular response. Augmenting this response may offer considerable clinical advantages such as optimizing the quality of regenerate formation, decreasing lengthy consolidation periods, or increasing regenerate size and distance. Using deferoxamine, an angiogenic transcriptional activator, the authors posit that substantial increases in vascular volume beyond the normal response to mechanical distraction can be quantified with micro-computed tomography after vessel perfusion during mandibular distraction osteogenesis.