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      Exosomal miR-6803-5p as potential diagnostic and prognostic marker in colorectal cancer.

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          Abstract

          Accumulating data have suggested exosome-delivered microRNAs (miRNAs) play critical role in carcinogenesis and cancer progression. However, little is known about the influence of exosomal miR-6803-5p on the development and prognosis of colorectal cancer (CRC). Levels of serum exosomal miR-6803-5p were determined by microarray analysis and verified by quantitative real-time PCR (qRT-PCR). Outcomes of overall survival (OS) and disease-free survival (DFS) of CRC patients were estimated by Kaplan-Meier analysis. We used cox regression analysis to investigate the association between exosomes-encapsulated miR-6803-5p and the clinicopathological factors of CRC patients. The exosomal miR-6803-5p was significantly increased in serum samples from patients with CRC in contrast to healthy controls. Significantly higher levels of serum exosomal miR-6803-5p were observed in CRC patients at later TNM stage or with lymph node metastasis as well as liver metastasis. Patients with elevated levels of serum exosomal miR-6803-5p had much poorer OS and DFS. Cox regression analysis revealed high levels of exosomal miR-6803-5p was associated with poor prognosis in CRC independent of other confounding factors. Thus, exosomal miR-6803-5p is a potential diagnostic and prognostic biomarker for patients with CRC.

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          Author and article information

          Journal
          J. Cell. Biochem.
          Journal of cellular biochemistry
          Wiley
          1097-4644
          0730-2312
          May 2018
          : 119
          : 5
          Affiliations
          [1 ] Department of Gastrointestinal and Anal Diseases Surgery, The Affiliated Hospital of Weifang Medical University, Weifang, China.
          [2 ] Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
          [3 ] Department of Cardiovascular, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.
          [4 ] Department of Physiology, Weifang Medical University, Weifang, China.
          [5 ] Functional Laboratory, Clinical Medicine College of Weifang Medical University, Weifang, China.
          [6 ] Department of Rheumatology and Immunology, The Affiliated Hospital of Weifang Medical University, Weifang, China.
          [7 ] Division of Gastrointestinal Surgery, Department of General Surgery, Huai'an Second People's Hospital, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
          Article
          10.1002/jcb.26609
          29240249

          microRNAs, colorectal cancer, exosomes

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