5
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Localization of pain‐related brain activation: A meta‐analysis of neuroimaging data

      research-article
      1 , 2 , , 3
      Human Brain Mapping
      Wiley Subscription Services, Inc., A Wiley Company
      pain, fMRI, PET, brain, human

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          A meta‐analysis of 140 neuroimaging studies was performed using the activation‐likelihood‐estimate (ALE) method to explore the location and extent of activation in the brain in response to noxious stimuli in healthy volunteers. The first analysis involved the creation of a likelihood map illustrating brain activation common across studies using noxious stimuli. The left thalamus, right anterior cingulate cortex (ACC), bilateral anterior insulae, and left dorsal posterior insula had the highest likelihood of being activated. The second analysis contrasted noxious cold with noxious heat stimulation and revealed higher likelihood of activation to noxious cold in the subgenual ACC and the amygdala. The third analysis assessed the implications of using either a warm stimulus or a resting baseline as the control condition to reveal activation attributed to noxious heat. Comparing noxious heat to warm stimulation led to peak ALE values that were restricted to cortical regions with known nociceptive input. The fourth analysis tested for a hemispheric dominance in pain processing and showed the importance of the right hemisphere, with the strongest ALE peaks and clusters found in the right insula and ACC. The fifth analysis compared noxious muscle with cutaneous stimuli and the former type was more likely to evoke activation in the posterior and anterior cingulate cortices, precuneus, dorsolateral prefrontal cortex, and cerebellum. In general, results indicate that some brain regions such as the thalamus, insula and ACC have a significant likelihood of activation regardless of the type of noxious stimuli, while other brain regions show a stimulus‐specific likelihood of being activated. Hum Brain Mapp, 2013. © 2011 Wiley Periodicals, Inc.

          Related collections

          Author and article information

          Contributors
          emma.duerden@sickkids.ca
          Journal
          Hum Brain Mapp
          Hum Brain Mapp
          10.1002/(ISSN)1097-0193
          HBM
          Human Brain Mapping
          Wiley Subscription Services, Inc., A Wiley Company (Hoboken )
          1065-9471
          1097-0193
          01 December 2011
          January 2013
          : 34
          : 1 ( doiID: 10.1002/hbm.v34.1 )
          : 109-149
          Affiliations
          [ 1 ]Département de physiologie, Groupe de recherche sur le système nerveux central, Université de Montréal, Montréal, Québec, Canada
          [ 2 ]Centre de recherche de l'institut universitaire de gériatrie de Montréal, Montréal, Québec, Canada
          [ 3 ]Department of Psychology, McGill University, Montréal, Québec, Canada
          Author notes
          [*] [* ]The Hospital for Sick Children, The Department of Diagnostic Imaging, 555 University Avenue, Toronto, ON, Canada, M5G 1Z8
          Article
          PMC6869965 PMC6869965 6869965 HBM21416
          10.1002/hbm.21416
          6869965
          22131304
          cbb45ef7-4d1a-47ca-ab04-5211bd61b5df
          Copyright © 2011 Wiley Periodicals, Inc.
          History
          : 26 January 2011
          : 28 May 2011
          : 05 July 2011
          Page count
          Figures: 1, Tables: 26, References: 232, Pages: 41, Words: 57263
          Funding
          Funded by: The Canadian Institutes of Health Research (CIHR)
          Categories
          Research Article
          Research Articles
          Custom metadata
          2.0
          January 2013
          Converter:WILEY_ML3GV2_TO_JATSPMC version:5.7.2 mode:remove_FC converted:15.11.2019

          brain,PET,fMRI,human,pain
          brain, PET, fMRI, human, pain

          Comments

          Comment on this article