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      Iridoid Derivatives with Cytotoxic Activity from Pedicularis uliginosa Bunge.

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          Abstract

          Three new iridoids, rel-(4aR,7S,7aS)-7-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carbaldehyde (1), 1-methoxy-7-methyl-1,3,5,6-tetrahydrocyclopenta[c]pyran-4-carbaldehyde (2), and rel-(1R,4S,4aS,7R,7aR)-7-methylhexahydro-1,4-(epoxymethano)cyclopenta[c]pyran-3(1H)-one (3), together with seven known analogues, were isolated from the 95 % EtOH extract of the whole plants of Pedicularis uliginosa Bunge. Their structures were elucidated via extensive NMR spectroscopy and mass spectral data. In terms of inhibitory effects on human tumor cells, compounds 1, 2, 6, 7, and 8 exhibited better inhibitory activities against ACHN cells than the positive control (vinblastine).

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          Author and article information

          Journal
          Chem Biodivers
          Chemistry & biodiversity
          Wiley
          1612-1880
          1612-1872
          Feb 2019
          : 16
          : 2
          Affiliations
          [1 ] State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P. R. China.
          Article
          10.1002/cbdv.201800524
          30468024
          cbbbed89-3c44-417a-8b9d-24161f6c8ecc
          © 2019 Wiley-VHCA AG, Zurich, Switzerland.
          History

          NMR spectroscopy,Pedicularis uliginosa Bunge,cytotoxicity,iridoids,structure elucidation

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