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      Increase in Bronchial Resistance during Infusion of Thrombin into the Venous Circulation of Guinea Pigs

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      Journal of Vascular Research

      S. Karger AG

      Thrombosis, Pulmonary embolism

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          Abstract

          Bronchial resistance was measured by the lung overflow technique in guinea pigs. Intravenous infusion of thrombin produced a significant increase of bronchial resistance, induced by platelet constituents released from the thrombi and deposited in the arteries and capillaries of the lung. This was evidenced by increase of bronchial resistance and mortality having been aggravated by e-aminocaproic acid (inhibition of fibrinolysis), by infusion of gelatin (sludge phenomenon) as well as by catecholamines (stress effect) and significantly inhibited by massive doses of heparin and by experimental thrombocytopenia. Emphasis is laid on the significance of pulmonary microembolism in the development of severe pulmonary hypertension and edema, the cause of which is difficult to diagnose clinically, yet demonstrable at autopsy. The recommended method is held to be suitable for the objective study of the process in animal experiment.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1973
          1973
          18 September 2008
          : 10
          : 3
          : 164-172
          Affiliations
          Egyt Pharmacochemical Works and Otto Korvin Hospital, Budapest
          Article
          157969 Angiologica 1973;10:164–172
          10.1159/000157969
          © 1973 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
          Categories
          Paper

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