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      Genetics of global gene expression.

      1 ,
      Nature reviews. Genetics
      Springer Science and Business Media LLC

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          Abstract

          A new field of genetic analysis of global gene expression has emerged in recent years, driven by the realization that traditional techniques of linkage and association analysis can be applied to thousands of transcript levels measured by microarrays. Genetic dissection of transcript abundance has shed light on the architecture of quantitative traits, provided a new approach for connecting DNA sequence variation with phenotypic variation, and improved our understanding of transcriptional regulation and regulatory variation.

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          Author and article information

          Journal
          Nat Rev Genet
          Nature reviews. Genetics
          Springer Science and Business Media LLC
          1471-0056
          1471-0056
          Nov 2006
          : 7
          : 11
          Affiliations
          [1 ] Lewis-Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA.
          Article
          nrg1964
          10.1038/nrg1964
          17047685
          cbe7eb0c-2a96-4413-bab2-b4eec5e56b99
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