For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
16
views
90
references
 Top references
cited by
13
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      81
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Ciclosporin 10 years on: indications and efficacy

      research-article
      Author(s): , BVM&S, DVD, MRCVS 1 , , MA, VetMB, DVD, MRCVS 2
      Publication date (Print):
      Journal: The Veterinary Record
      Publisher: BMJ Group

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Ciclosporin is a lipophilic cyclic polypeptide with powerful immunosuppressive and immunomodulatory properties that has been used in veterinary medicine for two decades. It is a calcineurin inhibitor whose principal mode of action is to inhibit T cell activation. The drug is principally absorbed from the small intestine and is metabolised in the intestine and liver by the cytochrome P450 enzyme system. Ciclosporin is known to interact with a wide range of pharmacological agents. Numerous studies have demonstrated good efficacy for the management of canine atopic dermatitis and this has been a licensed indication since 2003. In addition to the treatment of atopic dermatitis, it has been used as an aid in the management of numerous other dermatological conditions in animals including perianal fistulation, sebaceous adenitis, pododermatitis, chronic otitis externa and pemphigus foliaceus. This article reviews the mode of action, pharmacokinetics, indications for use and efficacy of ciclosporin in veterinary dermatology.

          Related collections

          Most cited references90

          • Record: found
          • Abstract: found
          • Article: not found

          Mechanisms of action of cyclosporine.

          Satoshi Matsuda, Shigeo Koyasu (2000)
          Cyclosporine (cyclosporin A, CsA) has potent immunosuppressive properties, reflecting its ability to block the transcription of cytokine genes in activated T cells. It is well established that CsA through formation of a complex with cyclophilin inhibits the phosphatase activity of calcineurin, which regulates nuclear translocation and subsequent activation of NFAT transcription factors. In addition to the calcineurin/NFAT pathway, recent studies indicate that CsA also blocks the activation of JNK and p38 signaling pathways triggered by antigen recognition, making CsA a highly specific inhibitor of T cell activation. Here we discuss the action of CsA on JNK and p38 activation pathways. We also argue the potential of CsA and its natural counterparts as pharmacological probes.
          Article 0 comments Cited 177 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            The mechanism of action of cyclosporin A and FK506.

            J Northrop, I Graef, N A Clipstone … (1996)
            The immunosuppressants cyclosporin A (CsA), FK506, and rapamycin suppress the immune response by inhibiting evolutionary conserved signal transduction pathways. CsA, FK506, and rapamycin bind to their intracellular receptors, immunophilins, creating composite surfaces that block the activity of specific targets. For CsA/cyclophilin and FK506/FKBP the target is calcineurin. Because of the large surface area of interaction of the drug-immunophilin complex with calcineurin, FK506 and CsA have a specificity for their biologic targets that is equivalent to growth factor-receptor interactions. To date, all the therapeutic as well as toxic effects of these drugs have been shown to be due to inhibition of calcineurin. Inhibition of the action of calcineurin results in a complete block in the translocation of the cytosolic component of the nuclear factor of activated T cells (NF-AT), resulting in a failure to activate the genes regulated by the NF-AT transcription factor. These genes include those required for B-cell help such as interleukin (IL-4) and CD40 ligand as well as those necessary for T-cell proliferation such as IL-2. The purpose of this article is to illustrate the means by which these drugs produce immunosuppression.
            Article 0 comments Cited 105 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Immunosuppressive agents in solid organ transplantation: Mechanisms of action and therapeutic efficacy.

              Vivienne Watson, Wayne E Bradley, L. Taylor (2005)
              Effective immunosuppression is an essential pre-requisite for successful organ transplantation and improvements in outcome after transplantation have to a large extent been dependent on developments in immunosuppressive therapy. Here we provide an overview of the different immunosuppressive agents currently used in solid organ transplantation. A historical perspective on the development of immunosuppression for organ transplantation is followed by a review of the individual agents, with a focus on their mechanism of action and efficacy. Steroids, anti-proliferative agents (azathioprine and mycophenolate), calcineurin inhibitors (cyclosporine and tacrolimus) and TOR inhibitors (sirolimus and everolimus) are discussed along with both polyclonal and monoclonal antibody preparations. Many of the key clinical trials that underpin current clinical usage of these agents are described and side-effects of the different agents are highlighted. Finally, a number of newer agents still in various stages of clinical development are briefly considered.
              Article 0 comments Cited 66 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Vet Rec
                Journal ID (iso-abbrev): Vet. Rec
                Journal ID (hwp): vetrec
                Journal ID (publisher-id): veterinaryrecord
                Title: The Veterinary Record
                Publisher: BMJ Group (BMA House, Tavistock Square, London, WC1H 9JR )
                ISSN (Print): 0042-4900
                ISSN (Electronic): 2042-7670
                Publication date (Print): March 2014
                Volume: 174
                Issue: Suppl 2 , The use of ciclosporin: a decade of experience in veterinary dermatology
                Pages: 13-21
                Affiliations
                [1 ]The Dermatology Referral Service, 528 Paisley Road West, Glasgow G51 1RN, UK
                [2 ]Rutland House Referral Hospital, Abbotsfield Road, St Helens, Merseyside WA9 4HU, UK
                Author notes

                Provenance: not commissioned; externally peer reviewed

                E-mail for correspondence: peter.forsythe@ 123456btconnect.com
                Article
                Publisher ID: vetrecg102484
                DOI: 10.1136/vr.102484
                PMC ID: 3995292
                PubMed ID: 24682697
                SO-VID: cbeb8519-6a37-453f-9c5f-c0206322a390
                Copyright © British Veterinary Association
                License:

                This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/

                History
                Categories
                Subject: 1506
                Subject: Review
                Custom metadata
                special-feature unlocked

                ScienceOpen disciplines: Veterinary medicine
                Data availability:
                ScienceOpen disciplines: Veterinary medicine

                Comments

                Comment on this article

                scite_

                Similar content81

                See all similar

                Cited by13

                See all cited by

                Most referenced authors746

                See all reference authors