- Record: found
- Abstract: found
- Article: not found
Discovery of a novel class of triazolones as checkpoint kinase inhibitors--hit to lead exploration.
Vibha Oza
1 ,
Susan Ashwell ,
Patrick Brassil ,
Jason Breed ,
Chun Deng ,
Jay Ezhuthachan ,
Heather Haye ,
Candice Horn ,
James Janetka ,
Paul Lyne ,
Nicholas Newcombe ,
Ludo Otterbien ,
Martin Pass ,
Jon Read ,
Sian Roswell ,
Mei Su ,
Dorin Toader ,
Dingwei Yu ,
Yan Yu ,
Anna Valentine ,
Peter Webborn ,
Ann White ,
Sonya Zabludoff ,
Xiaolan Zheng
Sep 01 2010
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Checkpoint Kinase-1 (Chk1, CHK1, CHEK1) is a Ser/Thr protein kinase that mediates cellular responses to DNA-damage. A novel class of Chk1 inhibitors, triazoloquinolones/triazolones (TZ's) was identified by high throughput screening. The optimization of these hits to provide a lead series is described.