Withanolides from aerial parts of Nicandra physalodes.

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Abstract

Twenty withanolides, including previously unknown nicanlodes A-M, were isolated from aerial parts of Nicandra physalodes. Their structural elucidations were unambiguously achieved through interpretation of extensive spectroscopic data (NMR and HRMS) and by comparison with literature data. Nicanlodes A and B have an unusual aromatic amine moiety. The isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines.

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Author and article information

Journal

Journal ID (iso-abbrev): Phytochemistry

Title: Phytochemistry

Publisher: Elsevier BV

ISSN (Electronic): 1873-3700

ISSN (Print): 0031-9422

Publication date (Electronic): May 2017

Volume: 137

Affiliations

[1 ] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Graduate University of the Chinese Academy of Sciences, Beijing 100049, China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China.

[2 ] Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.

[3 ] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.

[4 ] Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.

[5 ] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China.

[6 ] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.

[7 ] Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China. Electronic address: lihaizhou@yninfo.com.

[8 ] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China. Electronic address: mhchiu@mail.kib.ac.cn.