Correction: Epidemiology of multiple sclerosis in Iran: A systematic review and meta-analysis

Abstract

In the Results subsection of the Abstract, there are errors in the third and fourth sentence of the paragraph. The correct sentences are: The prevalence of MS in men and women was estimated to be 16.5/ 100,000 (95% CI: 13.3–20.5) and 44.8/ 100,000 (95% CI: 36.2–55.4), respectively. The incidence of MS in men was estimated to be 1.2/ 100,000 (95% CI: 1.0–1.4) and the incidence of MS in women was 48.2/ 100,000 (95% CI: 39.3–59.1). In the 3.1. Study characteristics and methodological quality subsection of the Results, there is an error in the third sentence of the paragraph. The correct sentence is: Finally, 39 articles (included 92 studies for prevalence and 34 studies for incidence) entered the meta-analysis process after qualitative assessment. In the 3.4. Prevalence of MS based on gender subsection of the Results, there is an error in the first sentence of the paragraph. The correct sentence is: The prevalence of MS in men and women was estimated to be 16.5/ 100,000 (95% CI: 13.3–20.5) and 44.8/ 100,000 (95% CI: 36.2–55.4), respectively (Fig 4). In the 3.7. Incidence of MS based on gender subsection of the Results, there is an error in the first sentence of the paragraph. The correct sentence is: The incidence of MS in men was estimated to be 1.2/ 100,000 (95% CI: 1.0–1.4) and the incidence of MS in women was 48.2/ 100,000 (95% CI: 39.3–59.1) (Fig 6). There is an error in Table 2. Please see the correct Table 2 here. 10.1371/journal.pone.0219466.t001 Table 2 MS prevalence based on region, gender, provinces, year of study and design. Variable Studies (N)* Sample (N) Heterogeneity 95% CI Pooled(Per 100,000) MS All I2 P-Value Region 12 different 1 19524 46695319 - - 41.2–42.4 42.4 All Iran 2 51962 145645451 99.97 < 0.001 20.4–57.4 34.2 Center 47 174229 368149059 99.94 < 0.001 28.6–43.1 35.1 East 8 3756 24011421 99.62 < 0.001 5.3–18.1 9.8 North 14 11640 32250226 99.50 < 0.001 18.7–32.0 24.5 South 13 17466 40504544 99.69 < 0.001 25.6–44.6 33.8 West 7 4237 12534786 98.01 < 0.001 22.4–41.9 30.6 Test for subgroup differences: Q = 45.66, df(Q) = 6, P< 0.001 Gender Male 31 25711 76907082 94.77 <0.0001 13.3–20.5 16.5 Female 31 74356 75432131 99.87 < 0.001 36.2–55.4 44.8 Rate ratio of female to male: OR = 3.01 (2.79–2 = 3.24, P<0.001) Province 12 different major provinces of Iran 1 19524 46695319 - - 41.2–42.4 41.8 Alborz 1 1737 2412513 - - 68.7–75.5 72.0 All Iran 2 51962 145645451 99.97 < 0.001 20.4–57.4 34.2 Ardabil 1 506 1248488 - - 37.1–44.2 40.5 Bushehr 1 33 103949 - - 22.6–44.7 31.7 Chahar Mahaal and Bakhtiari 1 537 895263 - - 55.1–65.3 60.0 East Azerbaijan 4 6971 1508315 99.74 < 0.001 25.8–67.4 41.7 Fars 4 11867 18441692 99.12 < 0.001 52.3–76.9 63.4 Golestan 1 373 1777014 - - 19.0–23.2 21.0 Guilan 2 1643 4961748 97.19 < 0.001 24.5–43.9 32.8 Hamadan 1 985 1758268 - - 52.6–59.6 56.0 Hormozgan 1 300 1578183 - - 17.0–21.3 19.0 Ilam 1 162 557599 - - 24.9–33.9 29.1 Isfahan 7 21302 32559015 99.79 < 0.001 43.5–79.3 58.7 Kerman 3 2102 6085168 85.39 < 0.001 31.0–40.4 35.4 Kermanshah 2 818 3890454 86.51 < 0.001 17.4–25.3 21.0 Khuzestan 4 3164 14295552 98.11 < 0.001 15.3–26.2 20.1 Kohgiluyeh and Boyer-Ahmad 3 1163 2030302 96.72 < 0.001 40.3–76.8 55.7 Kordestan 1 612 1493645 - - 37.9–44.4 41.0 Lorestan 1 351 1754244 - - 18.0–22.2 20.0 Markazi 1 862 1413959 - - 57.0–65.2 61.0 Mazandaran 2 1781 5996375 99.43 < 0.001 14.4–53.9 27.9 North Khorasan 3 332 2547026 92.70 < 0.001 8.3–18.8 12.5 Qazvin 1 192 1201565 - - 13.9–18.4 16.0 Qom 2 1180 2303344 0 0.60 4.03–44.9 42.5 Razavi Khorasan 2 2879 11587481 99.82 < 0.001 7.9–59.0 21.6 Semnan 1 353 631218 - - 50.4–62.1 55.9 Sistan and Balouchestan 5 771 11761406 75.34 < 0.001 5.6–7.5 6.5 South Khorasan 2 140 1298954 99.77 < 0.001 3.2–27.3 9.3 Tehran 28 146270 322611718 99.96 < 0.001 20.7–36.7 27.6 West Azerbaijan 1 1309 3080576 - - 4.03–44.9 42.5 Yazd 1 440 1074428 - - 37.3–45.0 41.0 Zanjan 1 193 1015734 - - 16.5–21.9 19.0 Test for subgroup differences: Q = 2559.92, df(Q) = 32, P< 0.001 Year of study < 1990 2 1110 17539552 69.13 0.072 5.7–7.0 6.3 1990–1994 5 4382 47222144 97.14 < 0.001 7.6–10.8 9.1 1995–1999 5 9763 53251981 98.62 < 0.001 15.1–21.3 17.9 2000–2004 5 20412 60955029 99.27 < 0.001 27.9–38.6 32.8 2005–2009 20 58545 182277428 99.82 < 0.001 15.5–23.6 19.1 2010–2014 51 151690 280165726 99.81 < 0.001 35.8–45.8 40.5 2015–2018 4 36912 28378946 99.76 < 0.001 50.7–85.0 65.6 Test for subgroup differences: Q = 744.07, df(Q) = 6, P< 0.001 Study design Population based 82 266175 627821102 99.83 < 0.001 27.0–35.9 31.1 Cross-sectional 10 16639 41969704 99.92 < 0.001 11.7–27.3 17.9 Test for subgroup differences: Q = 5.89, df(Q) = 1, P = 0.015 N: Number; CI: confidence interval * Some studies have been included and estimated the prevalence and incidence for more than 1 year and also regions. Each data was considered separately because of assessing the slope of prevalence and incidence in the years and estimating which region is the highest or lowest