Hematopoietic Stem Cell Transplantation Activity Worldwide in 2012 and a SWOT Analysis of the Worldwide Network for Blood and Marrow Transplantation Group (WBMT) including the global survey

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Abstract

Data on 68,146 hematopoietic stem cell transplants (HSCT) (53% autologous and 47% allogeneic) gathered by 1566 teams from 77 countries and reported through their regional transplant organizations were analyzed by main indication, donor type and stem cell source for the year 2012. With transplant rates ranging from 0.1 to 1001 per 10 million inhabitants, more HSCT were registered from unrelated 16,433 than related 15,493 donors. Grafts were collected from peripheral blood (66%), bone marrow (24%; mainly non-malignant disorders) and cord blood (10%). Compared to 2006, an increase of 46% total (57% allogeneic and 38% autologous) was observed. Growth was due to an increase in reporting teams (18%) and median transplant activity/team (from 38 to 48 HSCT/team). An increase of 67% was noted in mismatched/haploidentical family HSCT.

A SWOT analysis revealed the global perspective of WBMT to be its major strength and identified potential to be the key professional body for patients and authorities. The limited data collection remains its major weakness and threat.

In conclusion, global HSCT grows over the years without plateauing (allogeneic>autologous) and at different rates in the four WHO regions. Major increases were observed in allogeneic, haploidentical HSCT and, to a lesser extent, in cord blood.

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Author and article information

Journal

Journal ID (nlm-journal-id): 8702459

Journal ID (pubmed-jr-id): 2334

Journal ID (nlm-ta): Bone Marrow Transplant

Journal ID (iso-abbrev): Bone Marrow Transplant.

Title: Bone marrow transplantation

ISSN (Print): 0268-3369

ISSN (Electronic): 1476-5365

Publication date Nihms-submitted: 11 May 2016

Publication date (Electronic): 22 February 2016

Publication date (Print): June 2016

Publication date PMC-release: 01 June 2017

Volume: 51

Issue: 6

Pages: 778-785

Affiliations

[1 ]The Worldwide Network of Blood and Marrow Transplantation (WBMT) Transplant Activity Survey Office, University Hospital, Basel, Switzerland

[2 ]Hematology-Oncology Department, University Hospital, Leipzig, Germany

[3 ]The Australasian Bone Marrow Transplant Recipient Registry (ABMTRR), Royal Melbourne Hospital, Parkville, Victoria, Australia

[4 ]Institute for Operations Research and Computational Finances, University of St. Gallen, Switzerland

[5 ]The Eastern Mediterranean Blood and Marrow Transplant Group (EMBMT), King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

[6 ]Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan

[7 ]The Latin American Blood and Marrow Transplant Group (LABMT), Instituto Nacional de Cancer, Rio de Janeiro, Brazil

[8 ]National Marrow Donor Program, Minneapolis, USA

[9 ]Medical University of Graz, Division of Hematology, 8036 Graz, Austria

[10 ]The Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, USA

[11 ]The Asian Pacific Blood and Marrow Transplant Group (APBMT) Data Centre, Aichi Medical University, School of Medicine, Japan

[12 ]The Canadian Blood and Marrow Transplant Group (CBMTG), Princess Margaret Hospital, Toronto, Canada

[13 ]The European Blood and Marrow Transplant Group (EBMT), Hôpital St. Antoine, Paris

[14 ]The African Blood and Marrow Transplant Group, Johannesburg, South Africa (AFBMT)

[15 ]The World Health Organization WHO, Geneva, Switzerland

[16 ]Aichi Medical University, School of Medicine, Japan

[17 ]Hematology Department, Hammersmith Hospital, London, United Kingdom

[18 ]Pediatric Department, Hospital Samaritano, Sao Paulo, Brazil

Author notes

Address for correspondence: Prof. Dr. DietgerNiederwieser, WBMT activity survey office, University Hospital Basel, Switzerland, Petersgraben 4, CH 4031 Basel, Switzerland, Tel: + 4161 265 32 03, Fax: + 4161 265 27 35, dietger.niederwieser@ 123456medizin.uni-leipzig.de

Article

Accession ID: PMC4889523 Pmcid ID: PMC4889523 Pmc-uid ID: 4889523 Manuscript ID: nihpa783415

DOI: 10.1038/bmt.2016.18

PMC ID: 4889523

PubMed ID: 26901703

SO-VID: cc0b1962-dd0d-405b-8482-2d596fc25c65

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