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      The biochemistry of apoptosis.

      Nature

      physiology, Mitochondria, Humans, metabolism, Caspases, Apoptosis, Animals

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          Abstract

          Apoptosis--the regulated destruction of a cell--is a complicated process. The decision to die cannot be taken lightly, and the activity of many genes influence a cell's likelihood of activating its self-destruction programme. Once the decision is taken, proper execution of the apoptotic programme requires the coordinated activation and execution of multiple subprogrammes. Here I review the basic components of the death machinery, describe how they interact to regulate apoptosis in a coordinated manner, and discuss the main pathways that are used to activate cell death.

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          Author and article information

          Journal
          11048727
          10.1038/35037710

          Chemistry

          physiology, Mitochondria, Humans, metabolism, Caspases, Apoptosis, Animals

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