Understanding cellular and molecular mechanisms of pathogenesis of diabetic tendinopathy

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Abstract

There is accumulating evidence of an increased incidence of tendon disorders in people with diabetes mellitus. Diabetic tendinopathy is an important cause of chronic pain, restricted activity, and even tendon rupture in individuals. Tenocytes and tendon stem/progenitor cells (TSPCs) are the dominant cellular components associated with tendon homeostasis, maintenance, remodeling, and repair. Some previous studies have shown alterations in tenocytes and TSPCs in high glucose or diabetic conditions that might cause structural and functional variations in diabetic tendons and even accelerate the development and progression of diabetic tendinopathy. In this review, the biomechanical properties and histopathological changes in diabetic tendons are described. Then, the cellular and molecular alterations in both tenocytes and TSPCs are summarized, and the underlying mechanisms involved are also analyzed. A better understanding of the underlying cellular and molecular pathogenesis of diabetic tendinopathy would provide new insight for the exploration and development of effective therapeutics.

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Author and article information

Contributors

Pan-Pan Lu:

Comment :

Lu PP

Min-Hao Chen:

Comment :

Chen MH

Guang-Chun Dai:

Comment :

Dai GC

Ying-Juan Li:

Comment :

Li YJ

Liu Shi:

Comment :

Shi L

Yun-Feng Rui:

Comment :

Rui YF

Journal

Journal ID (nlm-ta): World J Stem Cells

Journal ID (publisher-id): WJSC

Title: World Journal of Stem Cells

Publisher: Baishideng Publishing Group Inc

ISSN (Electronic): 1948-0210

Publication date (Print): 26 November 2020

Publication date (Electronic): 26 November 2020

Volume: 12

Issue: 11

Pages: 1255-1275