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      Mechanisms and Concepts in RNA Virus Population Dynamics and Evolution

      1 , 2 , 2 , 2
      Annual Review of Virology
      Annual Reviews

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          THE RELATION OF RECOMBINATION TO MUTATIONAL ADVANCE.

          J. Müller (1964)
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            Some Genetic Aspects of Sex

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              Protein dynamism and evolvability.

              The traditional view that proteins possess absolute functional specificity and a single, fixed structure conflicts with their marked ability to adapt and evolve new functions and structures. We consider an alternative, "avant-garde view" in which proteins are conformationally dynamic and exhibit functional promiscuity. We surmise that these properties are the foundation stones of protein evolvability; they facilitate the divergence of new functions within existing folds and the evolution of entirely new folds. Packing modes of proteins also affect their evolvability, and poorly packed, disordered, and conformationally diverse proteins may exhibit high evolvability. This dynamic view of protein structure, function, and evolvability is extrapolated to describe hypothetical scenarios for the evolution of the early proteins and future research directions in the area of protein dynamism and evolution.
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                Author and article information

                Journal
                Annual Review of Virology
                Annu. Rev. Virol.
                Annual Reviews
                2327-056X
                2327-0578
                September 29 2018
                September 29 2018
                : 5
                : 1
                : 69-92
                Affiliations
                [1 ]Department of Biology, Stanford University, Stanford, California 94305, USA
                [2 ]Department of Microbiology and Immunology, University of California, San Francisco, California 94143, USA;
                Article
                10.1146/annurev-virology-101416-041718
                30048219
                cc28f18f-aca0-45fd-8757-21049a7faede
                © 2018
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