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      Zika Virus Alters the Expression Profile of microRNA-Related Genes in Liver, Lung, and Kidney Cell Lineages

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          First report of autochthonous transmission of Zika virus in Brazil

          In the early 2015, several cases of patients presenting symptoms of mild fever, rash, conjunctivitis and arthralgia were reported in the northeastern Brazil. Although all patients lived in a dengue endemic area, molecular and serological diagnosis for dengue resulted negative. Chikungunya virus infection was also discarded. Subsequently, Zika virus (ZIKV) was detected by reverse transcription-polymerase chain reaction from the sera of eight patients and the result was confirmed by DNA sequencing. Phylogenetic analysis suggests that the ZIKV identified belongs to the Asian clade. This is the first report of ZIKV infection in Brazil.
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            Inhibition of interferon signaling by dengue virus.

            Dengue virus is a worldwide-distributed mosquito-borne flavivirus with a positive strand RNA genome. Its transcribed polyprotein is cleaved by host- and virus-encoded peptidases into 10 proteins, some of which are of unknown function. Although dengue virus-infected cells seem to be resistant to the antiviral action of IFN, the viral products that mediate this resistance are unknown. Therefore, we have analyzed the ability of the 10 dengue virus-encoded proteins to antagonize the IFN response. We found that expression in human A549 cells of the dengue virus nonstructural proteins NS2A, NS4A, or NS4B enhances replication of an IFN-sensitive virus. Moreover, expression of NS4B and, to a lesser extent, of NS2A and NS4A proteins results in down-regulation of IFN-beta-stimulated gene expression. Cells expressing NS4B or infected with dengue virus do not exhibit nuclear signal transducer and activator of transcription (STAT) 1 on treatment with IFN-beta or IFN-gamma, indicating that NS4B might be involved in blocking IFN signaling during dengue virus infections. This protein, encoded by a positive strand RNA virus, is implicated as an IFN-signaling inhibitor.
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              ZIKA VIRUS INFECTION IN MAN.

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                Author and article information

                Journal
                Viral Immunology
                Viral Immunology
                Mary Ann Liebert Inc
                0882-8245
                1557-8976
                October 2018
                October 2018
                : 31
                : 8
                : 583-588
                Affiliations
                [1 ]Section of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ananindeua, Pará, Brazil.
                [2 ]Department of Morphology and Physiological Sciences, State University of Pará, Belém, Pará, Brazil.
                [3 ]Department of Pathology, State University of Pará, Belém, Pará, Brazil.
                Article
                10.1089/vim.2017.0186
                cc2d426e-e7d7-4dfd-98be-ed02e7029aed
                © 2018

                https://www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/

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