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      Codon usage and tRNA content in unicellular and multicellular organisms.

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      Molecular biology and evolution
      Oxford University Press (OUP)

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          Abstract

          Choices of synonymous codons in unicellular organisms are here reviewed, and differences in synonymous codon usages between Escherichia coli and the yeast Saccharomyces cerevisiae are attributed to differences in the actual populations of isoaccepting tRNAs. There exists a strong positive correlation between codon usage and tRNA content in both organisms, and the extent of this correlation relates to the protein production levels of individual genes. Codon-choice patterns are believed to have been well conserved during the course of evolution. Examination of silent substitutions and tRNA populations in Enterobacteriaceae revealed that the evolutionary constraint imposed by tRNA content on codon usage decelerated rather than accelerated the silent-substitution rate, at least insofar as pairs of taxonomically related organisms were examined. Codon-choice patterns of multicellular organisms are briefly reviewed, and diversity in G+C percentage at the third position of codons in vertebrate genes--as well as a possible causative factor in the production of this diversity--is discussed.

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          Author and article information

          Journal
          Mol Biol Evol
          Molecular biology and evolution
          Oxford University Press (OUP)
          0737-4038
          0737-4038
          Jan 1985
          : 2
          : 1
          Affiliations
          [1 ] Department of Biophysics, Faculty of Science, Kyoto University, Japan.
          Article
          10.1093/oxfordjournals.molbev.a040335
          3916708
          cc34c08c-66d7-4838-8e2e-d187097ab9d6
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