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      Predictive Value of Sequential Testing in Screening for Silent Myocardial Ischemia in Asymptomatic Middle-Aged Men (the ECCIS Project)

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          Abstract

          The accuracy of sequential testing in the noninvasive diagnosis of coronary artery disease has been established in the symptomatic clinical populations, while little is known about its value when applied to low prevalence groups, such as totally asymptomatic men. To evaluate the accuracy of noninvasive sequential testing in the diagnosis of silent myocardial ischemia, data were collected from exercise electrocardiogram, <sup>201</sup>Tl perfusion scintigraphy and radionuclide angiography for 62 totally asymptomatic middle-aged men who underwent coronary arteriography because they were positive for two or more markers of myocardial ischemia as determined by a diagnostic screening of a nonbiased population consisting of 4,842 presumably healthy men aged 40-59 years (the ECCIS Project). The predictive value of serial testing procedures for significant coronary artery obstruction was 35%. Predictive values of an abnormal electrocardiogram associated with either an abnormal <sup>201</sup>Tl scintigram, an abnormal isotopic ventriculography, or both were 33, 38 and 31%, respectively. In asymptomatic middle-aged men, there is at least a 50% likelihood that an abnormal radionuclide test is a false-positive result, and the positive predictive value is not enhanced by the concordance of an abnormal <sup>201</sup>Tl scintigraphy with an abnormal isotopic ventriculography. Thus, the application of noninvasive sequential testing in screening for asymptomatic coronary artery disease is limited by its low predictive value in accordance with the Bayesian probability theory.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1996
          1996
          19 November 2008
          : 87
          : 3
          : 240-243
          Affiliations
          aDivision of Cardiology, Ospedale di Careggi, Firenze, bLaboratory of Epidemiology and Biostatistics, Istituto Superiore di Sanità, Roma, cCentra per la Lotta contra Γlnfarto, Roma, dDivision of Cardiology A, Ospedale S. Camillo, Roma, and eDepartment of Cardiology, Ospedale Ca’Granda, Niguarda, Milano, Italy
          Article
          177094 Cardiology 1996;87:240–243
          10.1159/000177094
          8725321
          © 1996 S. Karger AG, Basel

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          Page count
          Pages: 4
          Categories
          Noninvasive and Diagnostic Cardiology

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