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      Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies.

      The British Journal of Nutrition

      Animals, Anti-Inflammatory Agents, Anticarcinogenic Agents, Antineoplastic Agents, Antioxidants, Cell Line, Cell Line, Tumor, Clinical Trials as Topic, Curcumin, adverse effects, therapeutic use, Disease Models, Animal, Dose-Response Relationship, Drug, Humans, Inflammatory Bowel Diseases, drug therapy, Neoplasms, prevention & control, Randomized Controlled Trials as Topic, Transcription Factors, drug effects

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          Curcumin is the active ingredient of turmeric. It is widely used as a kitchen spice and food colorant throughout India, Asia and the Western world. Curcumin is a major constituent of curry powder, to which it imparts its characteristic yellow colour. For over 4000 years, curcumin has been used in traditional Asian and African medicine to treat a wide variety of ailments. There is a strong current public interest in naturally occurring plant-based remedies and dietary factors related to health and disease. Curcumin is non-toxic to human subjects at high doses. It is a complex molecule with multiple biological targets and different cellular effects. Recently, its molecular mechanisms of action have been extensively investigated. It has anti-inflammatory, antioxidant and anti-cancer properties. Under some circumstances its effects can be contradictory, with uncertain implications for human treatment. While more studies are warranted to further understand these contradictions, curcumin holds promise as a disease-modifying and chemopreventive agent. We review the evidence for the therapeutic potential of curcumin from in vitro studies, animal models and human clinical trials.

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