To identify the white matter correlates of apathy and impulsivity in the major syndromes associated with frontotemporal lobar degeneration, using diffusion-weighted imaging and data from the PiPPIN (Pick's Disease and Progressive Supranuclear Palsy: Prevalence and Incidence) study. We included behavioral and language variants of frontotemporal dementia, corticobasal syndrome, and progressive supranuclear palsy.
Seventy patients and 30 controls underwent diffusion tensor imaging at 3-tesla after detailed assessment of apathy and impulsivity. We used tract-based spatial statistics of fractional anisotropy and mean diffusivity, correlating with 8 orthogonal dimensions of apathy and impulsivity derived from a principal component analysis of neuropsychological, behavioral, and questionnaire measures.
Three components were associated with significant white matter tract abnormalities. Carer-rated change in everyday skills, self-care, and motivation correlated with widespread changes in dorsal frontoparietal and corticospinal tracts, while carer observations of impulsive–apathetic and challenging behaviors revealed disruption in ventral frontotemporal tracts. Objective neuropsychological tests of cognitive control, reflection impulsivity, and reward responsiveness were associated with focal changes in the right frontal lobe and presupplementary motor area. These changes were observed across clinical diagnostic groups, and were not restricted to the disorders for which diagnostic criteria include apathy and impulsivity.
(1 Lundbeck, Shire, Teva - travel expenses (2) ECNP - travel expenses
Psychopharmacology, field editor since 1980. Honorarium. Current Opinion in the Behavioural Sciences, Mangaing editor since 2013, Honorarium
Oxford University Press, Neurobiology of Addiction (2009), Decision Making Affect and Learning (co-editor) (2011) Cognitive Search (co-editor) 2012 Translational Psychopharmacology (co-editor) (2017)
(1) A short guide to neuroimaging: the neuroscience of human cognition, Oxford University Press 2015
(1) 2012-2019 Medical Research Council, MC-A060-5PQ30,research support (2) 2012-2017 and 2017-2022 National Institute for Health Research, research support (2) 2017 Dementias Platform UK, research support
2012-2019 James F McDonnell Foundation, research support 2013, 2017 - Evelyn Trust, research support 2014 - Newton Trust, research support 2016 Holt fellowship, research support 2014, 2016 PSP Association, research support
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