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      Penetration of Radioactive Sulphate and Glucose from Hydrophilic Gel Contact Lenses into the Eye of the Rabbit

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          Abstract

          Soft poly(hydroxyethylmethacrylate) gel contact lenses soaked with a solution containing either radioactive sulphate or D-glucose-<sup>14</sup>C were applied to the rabbit eyes for time intervals ranging from 10 min to 24 h. It was estimated that the radioactive substances were released very rapidly from the contact lens; about 90% within the first hour of application. Radioactivity was then detected in the cornea, aqueous humour, crystalline lens, and vitreous in amounts decreasing with the duration of the experiment. A stepwise accumulation of radioactivity in the eye tissues and fluids was observed with sulphate but not with glucose.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1974
          1974
          03 December 2009
          : 6
          : 5-6
          : 291-300
          Affiliations
          Eye Research Laboratory and Isotope Laboratory of the Biological Institutes, Czechoslovak Academy of Sciences, and Department of Ophthalmology, Charles University, Prague
          Article
          264715 Ophthal Res 1974;6:291–300
          10.1159/000264715
          © 1974 S. Karger AG, Basel

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          Page count
          Pages: 10
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          Paper

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