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      Penetration of Radioactive Sulphate and Glucose from Hydrophilic Gel Contact Lenses into the Eye of the Rabbit


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          Soft poly(hydroxyethylmethacrylate) gel contact lenses soaked with a solution containing either radioactive sulphate or D-glucose-<sup>14</sup>C were applied to the rabbit eyes for time intervals ranging from 10 min to 24 h. It was estimated that the radioactive substances were released very rapidly from the contact lens; about 90% within the first hour of application. Radioactivity was then detected in the cornea, aqueous humour, crystalline lens, and vitreous in amounts decreasing with the duration of the experiment. A stepwise accumulation of radioactivity in the eye tissues and fluids was observed with sulphate but not with glucose.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          03 December 2009
          : 6
          : 5-6
          : 291-300
          Eye Research Laboratory and Isotope Laboratory of the Biological Institutes, Czechoslovak Academy of Sciences, and Department of Ophthalmology, Charles University, Prague
          264715 Ophthal Res 1974;6:291–300
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          : 20 July 1973
          : 10 September 1973
          Page count
          Pages: 10

          Vision sciences,Ophthalmology & Optometry,Pathology
          D-Glucose-14C,Contact lenses,Aqueous humour,Crystalline lens,Vitreous,Penetration into tissues,Poly(hydroxyethylmethacrylate) gel,Radioactive sulphate,Rabbit,Cornea


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