We provide a list of lizards, snakes, chelonians, and amphibians collected during a 30-day expedition to the Seridó Ecological Station (ESEC Seridó), Rio Grande do Norte state, Brazil. We sampled species using thirty-seven pitfall trap stations composed of four buckets each, along with glue traps and active searches. We recorded 13 species of lizards, eight snakes, 19 amphibians, and one chelonian. Rarefaction curves suggest local biodiversity is still underestimated. Sampling during rainy season was crucial to stabilize rarefaction curve for amphibians. Comparisons of our results with data from literature show we did not capture some arboreal and semifossorial lizards known for the area. Seridó Ecological Station fauna is characterized mainly by generalist species common to lowland Caatinga sites. Still, several Caatinga endemics species are found, which underscore the importance of this small but representative protected area.