+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Nephrotic Origin Hyperlipidemia, Relative Reduction of Vitamin E Level and Subsequent Oxidative Stress May Promote Atherosclerosis

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Background: The relation between nephrotic syndrome and atherosclerosis has not yet been fully clarified, although the high levels of low-density lipoprotein cholesterol usually found in this syndrome may give rise to atherosclerosis. This study was intended to test the disturbances of antioxidant/oxidant status in children with nephrotic syndrome (NS). Methods: 8 children in the active stage (AS) of NS , 7 children during the remission stage (REM) of NS, and 14 control subjects (CTRL) were enrolled into the study. The levels of plasma total cholesterol (TC), HDL-cholesterol (HDL-chol), LDL-cholesterol (LDL-chol), triglycerides (TG), vitamin E and 7-ketocholesterol (7KCH) before and after plasma saponification were measured. Results: A significant increase in the concentrations of TC, LDL-chol, vitamin E and total 7KCH in AS patients have been found. These patients had also a lower vitamin E/LDL-chol ratio. These changes have not been observed in the remission stage of nephrotic syndrome. Higher amounts of electronegatively charged-(oxidized) LDL particles as well as different oxysterols in AS patients have also been demonstrated. Conclusion: The study revealed significant disturbances in oxidant status during NS leading to plasma accumulation of oxidized LDL and cholesterol oxidation products that exert cytotoxicity and are known to induce atherosclerosis. We suggest that this may constitute an important link between nephrotic syndrome and atherosclerosis.

          Related collections

          Most cited references 2

          • Record: found
          • Abstract: not found
          • Article: not found

          Characterization of a more electronegatively charged LDL subfraction by ion exchange HPLC

            • Record: found
            • Abstract: not found
            • Article: not found

            Another cholesterol hypothesis: Cholesterol as antioxidant


              Author and article information

              S. Karger AG
              24 August 2001
              : 89
              : 1
              : 68-72
              aDepartment of Biochemistry, bClinic of Pediatry, and cDepartment of Biochemistry and Chemistry, Silesian Medical University, Katowice, Poland
              46046 Nephron 2001;89:68–72
              © 2001 S. Karger AG, Basel

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              Page count
              Figures: 1, Tables: 2, References: 27, Pages: 5
              Self URI (application/pdf):
              Original Paper

              Cardiovascular Medicine, Nephrology

              Oxysterols, Nephrotic syndrome, Oxidized LDL, Vitamin E


              Comment on this article